Evidence map›Paper›PMID 29870501›Full record

Trial reportSexually transmitted diseases2018

Sustained Sexual Behavior Change After Acute HIV Diagnosis in Malawi.

Katherine B Rucinski, Sarah E Rutstein, Kimberly A Powers, Dana K Pasquale, Ann M Dennis, Sam Phiri, Mina C Hosseinipour, Gift Kamanga, Dominic Nsona, Cecilia Massa and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Sexually transmitted diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Human Immunodeficiency Virus (HIV)-1 Transmission Among Persons With Acute HIV-1 Infection in Malawi: Demographic, Behavioral, and Phylogenetic Relationships.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Katherine B RucinskiFrom the Departments of Epidemiology and.
Sarah E RutsteinInfectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Kimberly A PowersFrom the Departments of Epidemiology and.
Dana K PasqualeFrom the Departments of Epidemiology and.
Ann M DennisInfectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Sam PhiriLighthouse Trust.
Mina C Hosseinipour
Gift KamangaUNC Project, Lilongwe, Malawi.
Dominic NsonaLighthouse Trust.
Cecilia MassaUNC Project, Lilongwe, Malawi.
Irving F HoffmanInfectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
William C MillerDepartment of Epidemiology, Ohio State University, Columbus, OH.
Audrey E PettiforFrom the Departments of Epidemiology and.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Acute HIV infection - A key link for transmission preventionR01AI083059 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, WILLIAM C, PETTIFOR, AUDREY · 2009 to 2012
$3.7M
Optimizing HIV Therapy: virological monitoring, adherence & cost-effectivenessF30MH098731 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUTSTEIN, SARAH E. · 2012 to 2016
$201k
NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI083059NIAID NIH HHS T32 AI070114NICHD NIH HHS P2C HD050924NIGMS NIH HHS T32 GM008719NIMH NIH HHS F30 MH098731
6 · The paper itself

Abstract

backgroundIdentification of acute HIV infection (AHI) allows for important opportunities for HIV prevention through behavior change and biomedical intervention. Here, we evaluate changes in sexual risk behaviors among persons with AHI enrolled in a combined behavioral and biomedical intervention designed to reduce onward transmission of HIV.

methodsParticipants were randomized to standard HIV counseling, a multisession behavioral intervention, or a multisession behavioral intervention plus antiretrovirals. Sexual behaviors were assessed periodically over 1 year.

resultsFour weeks after diagnosis, the predicted probability of reporting multiple sexual partners decreased from 24% to 9%, and the probability of reporting unprotected sex decreased from 71% to 27%. These declines in sexual risk behaviors were sustained over follow-up irrespective of study arm.

conclusionsDiagnosis of AHI alone may be sufficient to achieve immediate and sustained behavior change during this highly infectious period.

Indexed as

CounselingRisk-TakingAcute DiseaseAdultBehavior TherapyFemaleHIV InfectionsHumansMalawiMaleMass ScreeningRisk Reduction BehaviorSafe SexSexual BehaviorSexual PartnersUnsafe Sex

Identifiers

PMID29870501
PMCPMC6179914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.