Evidence map›Paper›PMID 29870278›Full record

ReviewFuture microbiology2018

The iron hand of uropathogenic Escherichia coli: the role of transition metal control in virulence.

Anne E Robinson, James R Heffernan, Jeffrey P Henderson

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Functional Characterization ofAntibiotics (Basel, Switzerland) · 2026
    Article
  12. Research Progress on perinatalFrontiers in microbiology · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. UropathogenicInternational journal of molecular sciences · 2025
    Article
  18. Whole-genome analysis of fiveMicrobiology spectrum · 2025
    Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anne E RobinsonDivision of Infectious Diseases, Department of Medicine, Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
James R HeffernanDivision of Infectious Diseases, Department of Medicine, Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey P HendersonDivision of Infectious Diseases, Department of Medicine, Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
EXPRESSION AND IRON-INDEPENDENT FUNCTIONS OF SIDEROPHORES IN URINARY TRACT INFECTR01DK099534 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2014 to 2018
$1.8M
Metabolomic Mechanisms of Nutritional Immunity in the Urinary TractR01DK111930 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2018 to 2021
$1.4M
NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK099534NIDDK NIH HHS R01 DK111930
6 · The paper itself

Abstract

The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract manipulates metal-ion availability in many ways to resist infection. For siderophore systems in particular, recent studies have identified new roles for siderophore copper binding as well as production of siderophore-like inhibitors of iron uptake by other, competing bacterial species. Among these is a process of nutritional passivation of metal ions, in which uropathogens access these vital nutrients while simultaneously protecting themselves from their toxic potential. Here, we review these new findings within the current understanding of UPEC transition metal acquisition.

Indexed as

AnimalsEscherichia coli InfectionsEscherichia coli ProteinsHumansIronSiderophoresUropathogenic Escherichia coliVirulenceEscherichia coli ProteinsIronSiderophores

Identifiers

PMID29870278
PMCPMC6161082
OpenAlexW2806524409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.