Evidence map›Paper›PMID 29870277›Full record

ArticleThe American journal of drug and alcohol abuse2019

Reliability and validity of an internalizing symptom scale based on the adolescent and adult Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA).

Laura Acion, John Kramer, Xiangtao Liu, Grace Chan, Douglas Langbehn, Kathleen Bucholz, Vivia McCutcheon, Victor Hesselbrock, Marc Schuckit, Danielle Dick and 2 more

Abstract readValidation Study
In one paragraph

Article in The American journal of drug and alcohol abuse, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura Aciona Department of Psychiatry , University of Iowa, Carver College of Medicine , Iowa City , IA, USA.
John Kramera Department of Psychiatry , University of Iowa, Carver College of Medicine , Iowa City , IA, USA.
Xiangtao Liua Department of Psychiatry , University of Iowa, Carver College of Medicine , Iowa City , IA, USA.
Grace Chand Department of Psychiatry , University of Connecticut Health Center , Farmington , CT, USA.
Douglas Langbehna Department of Psychiatry , University of Iowa, Carver College of Medicine , Iowa City , IA, USA.
Kathleen Bucholze Department of Psychiatry , Washington University School of Medicine , St. Louis , MO, USA.
Vivia McCutcheone Department of Psychiatry , Washington University School of Medicine , St. Louis , MO, USA.
Victor Hesselbrockd Department of Psychiatry , University of Connecticut Health Center , Farmington , CT, USA.
Marc Schuckitf Department of Psychiatry , University of California, San Diego School of Medicine , La Jolla , CA, USA.
Danielle Dickg Department of Psychology , Virginia Commonwealth University , Richmond , VA, USA.
Michie Hesselbrockd Department of Psychiatry , University of Connecticut Health Center , Farmington , CT, USA.
Samuel Kupermana Department of Psychiatry , University of Iowa, Carver College of Medicine , Iowa City , IA, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI Yunlong Liu · 1989 to 2026
$162.7M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
NEUROPHYSIOLOGY IN CHILDREN AT HIGH RISK FOR ALCOHOLISMR37AA005524 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI PORJESZ, BERNICE · 2001 to 2010
$4.6M
NEUROPHYSIOLOGY IN CHILDREN AT HIGH RISK FOR ALCOHOLISMR01AA005524 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI PORJESZ, BERNICE · 1986 to 2015
$3.0M
ETHANOL TOLERANCE IN NEUROHYPOPHYSISF31AA005524 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KNOTT, THOMAS KRIS · 1998 to 2000
$9k
NIAAA NIH HHS F31 AA005524NIAAA NIH HHS R01 AA005524NIAAA NIH HHS R37 AA005524NIAAA NIH HHS U10 AA008401
6 · The paper itself

Abstract

backgroundThe Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) is an interview that assesses psychiatric symptoms and diagnoses, including substance use disorders and anxiety and mood (i.e., internalizing) disorders. Although the SSAGA is widely used, there exists no overall internalizing characteristics scale based on items drawn from SSAGA's mood and anxiety disorder sections.

objectivesTo design and assess a SSAGA-based measurement instrument capturing the overall internalizing dimension that underlies more specific internalizing conditions.

methodsWe developed, assessed, and characterized a new scale for measuring internalizing problematic characteristics derived from the SSAGA interview. All samples were drawn from the Collaborative Studies on the Genetics of Alcoholism, a prospective multi-site genetic study of families at high risk for alcohol use disorders. All participants taking part in the study between September 2005 and September 2017 were eligible (n = 904, 52.2% female).

resultsThe scale had adequate internal consistency (ordinal α = 0.85, 95% CI = [0.81, 0.89]). Construct validity was supported by its association with other measures of internalizing characteristics (Internalizing Scale from Achenbach Self Reports; Neuroticism Scale from the Neuroticism-Extraversion-Openness Five-Factor Personality Inventory). Several indices of alcohol, marijuana, and nicotine misuse were also positively associated with Internalizing Scale scores.

conclusionsThe Internalizing Scale has very good psychometric properties and can be used in studies that incorporate the SSAGA interview to study the association between internalizing characteristics and problematic alcohol and other substance use. These associations can potentially be utilized to identify individuals at risk for substance problems and to design treatments targeting such individuals.

Indexed as

Interview, PsychologicalAdolescentAdolescent Health ServicesAlcohol-Related DisordersFemaleGenetic Predisposition to DiseaseHumansMalePersonality InventoryProspective StudiesReproducibility of ResultsSelf ReportYoung AdultalcoholismInternalizingscale

Identifiers

PMID29870277
PMCPMC6481182

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.