Evidence map›Paper›PMID 29870068›Full record

ReviewPacing and clinical electrophysiology : PACE2018

J wave syndromes as a cause of malignant cardiac arrhythmias.

José M Di Diego, Charles Antzelevitch

Abstract readReview
In one paragraph

Review in Pacing and clinical electrophysiology : PACE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. The "Five Malignant Waves" of the Eletrocardiography.Arquivos brasileiros de cardiologia · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Inter-Regulation of KInternational journal of molecular sciences · 2020
    Article
  6. Article
  7. Electrophysiological Basis for Early Repolarization Syndrome.Frontiers in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

José M Di DiegoLankenau Institute for Medical Research, Wynnewood, PA, USA.
Charles AntzelevitchLankenau Institute for Medical Research, Wynnewood, PA, USA.ORCID 0000-0001-7349-1582
Lankenau Institute for Medical Research · USThomas Jefferson University · US

Funding

ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
Development of a whole heart model of the J wave syndromes and novel approaches to pharmacologic management of associated life-threatening arrhythmiasR01HL152201 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES, DI DIEGO, JOSE M. · 2020 to 2023
$2.5M
Novel Approaches to Pharmacologic Management of Life-Threatening Arrhythmias Associated with the J Wave SyndromesR56HL138103 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES · 2018 to 2018
$413k
ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR55HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1992 to 1992
–
NHLBI NIH HHS HL47678NHLBI NIH HHS R01 HL047678NHLBI NIH HHS R01 HL152201NHLBI NIH HHS R56 HL138103
6 · The paper itself

Abstract

The J wave syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes, are characterized by the manifestation of prominent J waves in the electrocardiogram appearing as an ST segment elevation and the development of life-threatening cardiac arrhythmias. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite over 25 years of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still rapidly evolving. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular, and genetic mechanisms underlying these two syndromes that have captured the interest and attention of the cardiology community over the past two decades.

Indexed as

Arrhythmias, CardiacBrugada SyndromeCardiac Conduction System DiseaseElectrocardiographyHumansBrugada syndromecardiac arrhythmiasearly repolarization syndromeinherited cardiac arrhythmias syndromesudden cardiac deathventricular fibrillationventricular tachycardia

Identifiers

PMID29870068
PMCPMC6281786
OpenAlexW2805183646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.