ArticleMolecular plant-microbe interactions : MPMI2018
Heat-Shock Proteins MoSsb1, MoSsz1, and MoZuo1 Attenuate MoMkk1-Mediated Cell-Wall Integrity Signaling and Are Important for Growth and Pathogenicity of Magnaporthe oryzae.
Article in Molecular plant-microbe interactions : MPMI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
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- Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections.Microorganisms · 2023Review
- The transcriptional landscape of plant infection by the rice blast fungus Magnaporthe oryzae reveals distinct families of temporally co-regulated and structurally conserved effectors.The Plant cell · 2023Article
- MoMaf1 Mediates Vegetative Growth, Conidiogenesis, and Pathogenicity in the Rice Blast FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Pyridoxine biosynthesis protein MoPdx1 affects the development and pathogenicity ofFrontiers in cellular and infection microbiology · 2023Article
- Homeostasis of cell wall integrity pathway phosphorylation is required for the growth and pathogenicity of Magnaporthe oryzae.Molecular plant pathology · 2022Article
- Comparative Proteomic Analysis ofJournal of fungi (Basel, Switzerland) · 2022Article
- Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi.Archives of microbiology · 2022Review
- The Coupling Between Cell Wall Integrity Mediated by MAPK Kinases and SsFkh1 Is Involved in Sclerotia Formation and Pathogenicity ofFrontiers in microbiology · 2022Article
- Regulation of biotic interactions and responses to abiotic stresses by MAP kinase pathways in plant pathogenic fungi.Stress biology · 2021Review
- Transcriptional Responses ofFrontiers in cellular and infection microbiology · 2021Article
- Conserved Eukaryotic Kinase CK2 Chaperone Intrinsically Disordered Protein Interactions.Applied and environmental microbiology · 2020Article
- Systematic Analysis of Lysine Lactylation in the Plant Fungal PathogenFrontiers in microbiology · 2020Article
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- Study on Differential Protein Expression in Natural Selenium-Enriched and Non-Selenium-Enriched Rice Based on iTRAQ Quantitative Proteomics.Biomolecules · 2019Article
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- The ER Lumenal Hsp70 Protein FpLhs1 Is Important for Conidiation and Plant Infection inFrontiers in microbiology · 2019Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The mitogen-activated protein kinase (MAPK) MoMkk1 governs the cell-wall integrity (CWI) pathway in rice blast fungus Magnaporthe oryzae. To understand the underlying mechanism, we have identified MoSsb1 as one of the MoMkk1-interacting proteins. MoSsb1 is a stress-seventy subfamily B (Ssb) protein homolog, sharing high amino acid sequence homology with the 70-kDa heat shock proteins (Hsp70s). Hsp70 are a family of conserved and ubiquitously expressed chaperones that regulate protein biogenesis by promoting protein folding, preventing protein aggregation, and controlling protein degradation. We found that MoSsb1 regulates the synthesis of nascent polypeptide chains and this regulation is achieved by being in complex with other members of Hsp70s MoSsz1 and 40-kDa Hsp40 MoZuo1. MoSsb1 is important for the growth, conidiation, and full virulence of the blast fungus and this role is also shared by MoSsz1 and MoZuo1. Importantly, MoSsb1, MoSsz1, and MoZuo1 are all involved in the regulation of the CWI MAPK pathway by modulating MoMkk1 biosynthesis. Our studies reveal novel insights into how MoSsb1, MoSsz1, and MoZuo1 affect CWI signaling that is involved in regulating growth, differentiation, and virulence of M. oryzae and highlight the conserved functional mechanisms of heat-shock proteins in pathogenic fungi.
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