Evidence map›Paper›PMID 29869931›Full record

ArticlePulmonary circulation

Crosstalk signaling between alveoli and capillaries.

Rebecca F Hough, Sunita Bhattacharya, Jahar Bhattacharya

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca F Hough1 Lung Biology Lab, Columbia University College of Physicians & Surgeons, New York, NY, USA.
Sunita Bhattacharya1 Lung Biology Lab, Columbia University College of Physicians & Surgeons, New York, NY, USA.
Jahar Bhattacharya1 Lung Biology Lab, Columbia University College of Physicians & Surgeons, New York, NY, USA.
Columbia University · US

Funding

MICROPUNCTURE STUDIES OF LUNG, WATER AND SOLUTE EXCHANGER01HL036024 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1985 to 2025
$7.0M
NHLBI NIH HHS R01 HL036024
6 · The paper itself

Abstract

Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung's immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.

Indexed as

acute lung injuryacute respiratory distress syndromesalveolarARDScapillarieslung repair and regeneration

Identifiers

PMID29869931
PMCPMC6024290
OpenAlexW2807571008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.