ArticleThe British journal of radiology2018
Utility of quantitative apparent diffusion coefficient measurements and normalized apparent diffusion coefficient ratios in the diagnosis of clinically significant peripheral zone prostate cancer.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Accuracy of multiparametric magnetic resonance imaging for diagnosing prostate Cancer: a systematic review and meta-analysis.BMC cancer · 2019Pooled it
- Quantitative assessment of prostate cancer using an individualized apparent diffusion coefficient intensity scale: a proposal.Quantitative imaging in medicine and surgery · 2026Article
- Prognostic value of MRI-derived features for biochemical recurrence after curative radiotherapy in prostate cancer.Abdominal radiology (New York) · 2026Article
- Article
- bp-VI-RADS combined with normalized apparent diffusion coefficient enhances diagnostic efficacy for muscle-invasive bladder cancer.Quantitative imaging in medicine and surgery · 2026Article
- Cross-Scanner Harmonization of AI/DL Accelerated Quantitative Bi-Parametric Prostate MRI.Sensors (Basel, Switzerland) · 2025Article
- Editorial for "Significance of Normalized Apparent Diffusion Coefficient in the Vesical Imaging-Reporting and Data System for Diagnosing Muscle-Invasive Bladder Cancer".Journal of magnetic resonance imaging : JMRI · 2024Article
- Biparametric prostate MRI: impact of a deep learning-based software and of quantitative ADC values on the inter-reader agreement of experienced and inexperienced readers.La Radiologia medica · 2022Article
- DWI-related texture analysis for prostate cancer: differences in correlation with histological aggressiveness and data repeatability between peripheral and transition zones.European radiology experimental · 2022Article
- Prostate minimally invasive procedures: complications and normal vs. abnormal findings on multiparametric magnetic resonance imaging (mpMRI).Abdominal radiology (New York) · 2021Review
- A 3D-2D Hybrid U-Net Convolutional Neural Network Approach to Prostate Organ Segmentation of Multiparametric MRI.AJR. American journal of roentgenology · 2021Article
- Calculation of Apparent Diffusion Coefficients in Prostate Cancer Using Deep Learning Algorithms: A Pilot Study.Frontiers in oncology · 2021Article
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Authors and funding
9 authors.
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Abstract
objectiveThe aim of this study is to evaluate the utility of quantitative apparent diffusion coefficient (ADC) measurements and normalized ADC ratios in multiparametric MRI for the diagnosis of clinically significant peripheral zone (PZ) prostate cancer particularly among equivocally suspicious prostate lesions.
methodsA retrospective analysis of 95 patients with PZ lesions by PI-RADSv2 criteria, and who underwent subsequent MRI-US fusion biopsy, was approved by an institutional review board. Two radiologists independently measured ADC values in regions of interest (ROIs) of PZ lesions and calculated normalized ADC ratio based on ROIs in the bladder lumen. Diagnostic performance was evaluated using ROC. Inter observer variability was assessed using intraclass correlation coefficient (ICC).
resultsMean ADC and normalized ADC ratios for clinically significant and non-clinically significant lesions were 0.763 × 10-3 mm
conclusionQuantitative ADC measurement in PZ prostate lesions demonstrates excellent diagnostic performance in differentiating clinically significant from non-clinically significant prostate cancer with high inter observer correlation. Advances In knowledge: Quantitative ADC is presented as an additional method to evaluate lesions in mpMRI of the prostate. This technique may be incorporated in new and existing methods to improve detection and discrimination of clinically significant prostate cancer.
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