Evidence map›Paper›PMID 29869786›Full record

ArticleThe Journal of physiology2018

Long-term high altitude hypoxia during gestation suppresses large conductance Ca

Xiang-Qun Hu, Chiranjib Dasgupta, Jeffery Xiao, Shumei Yang, Lubo Zhang

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. The uteroplacental circulation at high altitude: adaptation and maladaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  2. CaInternational journal of molecular sciences · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Review
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  8. Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Epigenetic down-regulation of BKInternational journal of cardiology · 2019
    Article
  15. Effect of Oxidative Stress on the Estrogen-NOS-NO-KOxidative medicine and cellular longevity · 2019
    Review
  16. miRNA-210: a hypoxamiRyad of possibilities.The Journal of physiology · 2018
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiang-Qun HuThe Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Chiranjib DasguptaThe Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Jeffery XiaoThe Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Shumei YangDepartment of Chemistry and Biochemistry, California State University, San Bernardino, CA, USA.
Lubo ZhangThe Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.ORCID 0000-0002-9386-8938
Loma Linda University · USCalifornia State University, San Bernardino · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Uterine Arterial Spontaneous Transient Outward Currents in PregnancyR01HL137649 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2017 to 2020
$1.6M
HHS | National Institutes of Health (NIH) HL137649NHLBI NIH HHS R01 HL137649NICHD NIH HHS P01 HD083132
6 · The paper itself

Abstract

key pointsGestational hypoxia represses ten-eleven translocation methylcytosine dioxygenase 1 (TET1) expression in uterine arteries, which is recovered by inhibiting endogenous miR-210. Inhibition of miR-210 rescues BK ABSTRACT: Gestational hypoxia at high altitude has profound adverse effects on the uteroplacental circulation, and is associated with increased incidence of preeclampsia and fetal intrauterine growth restriction. Previous studies demonstrated that suppression of large-conductance Ca

Indexed as

MicroRNAsAltitude SicknessAnimalsFemaleMixed Function OxygenasesPotassium Channels, Calcium-ActivatedPregnancyProto-Oncogene ProteinsSheepUterine ArteryMicroRNAsMixed Function OxygenasesPotassium Channels, Calcium-ActivatedProto-Oncogene Proteinschannelepigeneticvascular tone

Identifiers

PMID29869786
PMCPMC6265561
OpenAlexW2890906791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.