ArticleeLife2018
Uncovering temporal structure in hippocampal output patterns.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026Article
- Article
- A likelihood-based method for identifying replay from spike sequences.Nature communications · 2026Article
- History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex.The Journal of physiology · 2026Article
- Replay without sharp wave ripples in a spatial memory task.Nature communications · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.bioRxiv : the preprint server for biology · 2025Article
- Article
- A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.bioRxiv : the preprint server for biology · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.PloS one · 2025Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- Connecting the dots in the zona incerta: A study of neural assemblies and motifs of inter-area coordination in mice.iScience · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Temporal progression along discrete coding states during decision-making in the mouse gustatory cortex.PLoS computational biology · 2023Article
- Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity.PLoS computational biology · 2022Article
- Disarrangement and reorganization of the hippocampal functional connectivity during the spatial path adjustment of pigeons.BMC zoology · 2022Article
- Review
- Metastable dynamics of neural circuits and networks.Applied physics reviews · 2022Review
- Metastable attractors explain the variable timing of stable behavioral action sequences.Neuron · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Place cell activity of hippocampal pyramidal cells has been described as the cognitive substrate of spatial memory. Replay is observed during hippocampal sharp-wave-ripple-associated population burst events (PBEs) and is critical for consolidation and recall-guided behaviors. PBE activity has historically been analyzed as a phenomenon subordinate to the place code. Here, we use hidden Markov models to study PBEs observed in rats during exploration of both linear mazes and open fields. We demonstrate that estimated models are consistent with a spatial map of the environment, and can even decode animals' positions during behavior. Moreover, we demonstrate the model can be used to identify hippocampal replay without recourse to the place code, using only PBE model congruence. These results suggest that downstream regions may rely on PBEs to provide a substrate for memory. Additionally, by forming models independent of animal behavior, we lay the groundwork for studies of non-spatial memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.