ArticleThe American journal of tropical medicine and hygiene2018
Watch and Wait Approach for Inactive Echinococcal Cyst of the Liver: An Update.
Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Treatment of uncomplicated hepatic cystic echinococcosis (hydatid disease).The Cochrane database of systematic reviews · 2024Pooled it
- A Multicenter Retrospective Study of Cystic and Alveolar Echinococcosis Patients in the United States (1997-2024).The American journal of tropical medicine and hygiene · 2026Observational
- Detection of Echinococcus granulosus sensu lato microRNAs in cystic echinococcosis patients: An exploratory study using quantitative PCR and digital PCR.PLoS neglected tropical diseases · 2025Article
- Design and evaluation of a novel direct hemagglutination test based on a recombinant protein for diagnosis of cystic echinococcosis.Parasites & vectors · 2025Article
- Pulmonary manifestations and clinical management of echinococcosis in a low-endemic region of Mexico: a 15-year retrospective cohort study at a tertiary hospital.Tropical medicine and health · 2025Article
- Cystic Echinococcosis in the Early 2020s: A Review.Tropical medicine and infectious disease · 2024Review
- Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?Parasitology research · 2023Article
- What do we know about the epidemiology and the management of human echinococcosis in Albania?Parasitology research · 2023Article
- Antigen discovery by bioinformatics analysis and peptide microarray for the diagnosis of cystic echinococcosis.PLoS neglected tropical diseases · 2023Article
- Identification of B-cell dominant epitopes in the recombinant protein P29 from Echinococcus granulosus.Immunity, inflammation and disease · 2022Article
- Identification of a dominant murine T-cell epitope in recombinant protein P29 from Echinococcus granulosusActa biochimica et biophysica Sinica · 2022Article
- Accuracy of an experimental whole-blood test for detecting reactivation of echinococcal cysts.PLoS neglected tropical diseases · 2021Article
- Treatment of a giant hepatic echinococcal cyst with percutaneous drainage and in vivo assessment of the protoscolicidal effect of praziquantel.Clinical journal of gastroenterology · 2021Article
- Cystic Echinococcosis: Clinical, Immunological, and Biomolecular Evaluation of Patients from Sardinia (Italy).Pathogens (Basel, Switzerland) · 2020Article
- Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers.PLoS neglected tropical diseases · 2020Article
- The European Register of Cystic Echinococcosis, ERCE: state-of-the-art five years after its launch.Parasites & vectors · 2020Article
- Authors' Response.The American journal of tropical medicine and hygiene · 2020Article
- Comment on: "Complications Associated with Initial Clinical Presentation of Cystic Echinococcosis: A 20-year Cohort Analysis".The American journal of tropical medicine and hygiene · 2020Article
- Standardized endocystectomy technique for surgical treatment of uncomplicated hepatic cystic echinococcosis.PLoS neglected tropical diseases · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cystic echinococcosis (CE) is a chronic, complex and neglected infection causing severe disease in humans. Hepatic CE cysts are detected and classified mainly by using ultrasound. Expert opinion and published data suggest that uncomplicated inactive liver cysts do not require treatment and only need to be monitored over time ("Watch and Wait"). Here we update our findings as published in 2014 on the "Watch and Wait" approach applied to inactive, asymptomatic cysts of the liver to keep the medical community informed. Clinical data of patients who accessed the World Health Organization Collaborating Center for CE at the University of Pavia-San Matteo Hospital Foundation from January 1991 to October 2017 were analyzed. Inclusion criteria were presence of one or more inactive uncomplicated cysts in the liver (CE4 or CE5), without any history of previous treatment, and an ultrasound-based follow-up of at least 24 months. Fifty-three patients with 66 inactive cysts fulfilled the inclusion criteria. Of these, 11 patients are newly described here; 37 were part of our previously described cohort and the follow-up for 17 of them was further extended; and five were excluded from the previously published analysis as their follow-up was too short, but could be included now. Without the need for treatment and without development of complications, 98.5% of cysts remained inactive over time. In only one patient (1.9% of patients), a reactivation of one cyst (1.5% of cysts) was observed.
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