Evidence map›Paper›PMID 29869530›Full record

ArticleHuman gene therapy2018

DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination.

Xintao Hu, Antonio Valentin, Yanhui Cai, Frances Dayton, Margherita Rosati, Eric G Ramírez-Salazar, Viraj Kulkarni, Kate E Broderick, Niranjan Y Sardesai, Linda S Wyatt and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Human gene therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. SARS-CoV-2 Vaccine Development: An Overview and Perspectives.ACS pharmacology & translational science · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Xintao Hu1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
Antonio Valentin2 Human Retrovirus Section, National Cancer Institute, Frederick, Maryland.
Yanhui Cai1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
Frances Dayton1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
Margherita Rosati2 Human Retrovirus Section, National Cancer Institute, Frederick, Maryland.
Eric G Ramírez-Salazar1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
Viraj Kulkarni1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
Kate E Broderick3 Inovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.
Niranjan Y Sardesai3 Inovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.
Linda S Wyatt4 Laboratory of Viral Diseases, NIAID, Bethesda, Maryland.
Patricia L Earl4 Laboratory of Viral Diseases, NIAID, Bethesda, Maryland.
Bernard Moss4 Laboratory of Viral Diseases, NIAID, Bethesda, Maryland.
James I Mullins5 University of Washington , Seattle, Washington.
George N Pavlakis2 Human Retrovirus Section, National Cancer Institute, Frederick, Maryland.
Barbara K Felber1 Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, Maryland.
National Cancer Institute · USInovio Pharmaceuticals (United States) · USUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Immunotherapeutic Approaches for AIDSZIABC010749 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLAKIS, GEORGE N. · 2009 to 2022
$21.6M
Viral Determinants of HIV-1 Transmission in African HeterosexualsP01AI057005 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2003 to 2014
$20.5M
Recombinant Virus VaccinesZIAAI000416 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MOSS, BERNARD · 2009 to 2025
$17.3M
Posttranscriptional control of gene expressionZIABC010334 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FELBER, BARBARA K · 2009 to 2025
$15.1M
NIAID NIH HHS P01 AI057005NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

DNA-based vaccines able to induce efficient cytotoxic T-cell responses targeting conserved elements (CE) of human immunodeficiency virus type 1 (HIV-1) Gag have been developed. These CE were selected by stringent conservation, the ability to induce T-cell responses with broad human leukocyte antigen coverage, and the association between recognition of CE epitopes and viral control in HIV-infected individuals. Based on homology to HIV, a simian immunodeficiency virus p27

Indexed as

AIDS VaccinesAnimalsCD4-Positive T-LymphocytesCytotoxicity, ImmunologicDNAHIV-1HIV InfectionsHumansImmunization, SecondaryMacaca mulattaSimian Immunodeficiency VirusT-Lymphocytes, CytotoxicVaccines, DNAVacciniaVaccinia virusAIDS VaccinesDNAVaccines, DNAdurabilityelectroporationimmunizationlong-lastingmacaquevaccinationvaccine

Identifiers

PMID29869530
PMCPMC6152849
OpenAlexW2807563658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.