Evidence map›Paper›PMID 29869405›Full record

Trial reportBipolar disorders2018

Adjunctive thyroid hormone treatment in rapid cycling bipolar disorder: A double-blind placebo-controlled trial of levothyroxine (L-T

Patricia D Walshaw, Laszlo Gyulai, Michael Bauer, Mark S Bauer, Brian Calimlim, Catherine A Sugar, Peter C Whybrow

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Characteristics of rapid cycling in 1261 bipolar disorder patients.International journal of bipolar disorders · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Role of thyroid hormone therapy in depressive disorders.Journal of endocrinological investigation · 2021
    Review
  19. Article
  20. Thyroid Function and Mood Disorders: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Patricia D WalshawDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, California, USA.ORCID 0000-0002-4080-595X
Laszlo GyulaiDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Mark S BauerDepartment of Psychiatry, VA Boston Healthcare System, Harvard Medical School & the Center for Healthcare Organization and Implementation Research, Boston, Massachusetts, USA.
Brian CalimlimDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Catherine A SugarDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Peter C WhybrowDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, California, USA.
University of California, Los Angeles · USVA Boston Healthcare System · USPhiladelphia VA Medical Center · US

Funding

THYROID AXIS EPISODIC BEHAVIOR AND AFFECTIVE ILLNESSP01MH044210 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WHYBROW, PETER C · 1989 to 1993
–
NIMH NIH HHS P01 MH044210
6 · The paper itself

Abstract

objectivesThis report describes the first comparative double-blind, placebo-controlled trial of levothyroxine (L-T

methodsThirty-two treatment-resistant, rapid cycling patients who had failed a trial of lithium were randomized into three treatment arms: L-T

resultsThere were no statistically significant differences between the groups in age, gender, duration of illness, or thyroid status. Markov chain analyses were employed to assess treatment effects on cycling patterns among mood states (euthymia, depression, mania, and mixed). Within groups, post-treatment the L-T

conclusionsThe findings in this first double-blind study directly comparing the effects of L-T

Indexed as

Bipolar DisorderThyroxineTriiodothyronineAdultAffectDouble-Blind MethodFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesThyroid Function TestsThyroid HormonesTime FactorsTreatment OutcomeThyroid HormonesThyroxineTriiodothyroninebipolar disorderlevothyroxinerapid cyclingthyroidtriiodothyronine

Identifiers

PMID29869405
PMCPMC6323302
OpenAlexW2898333422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.