ArticleJournal of assisted reproduction and genetics2018
Decreased pregnancy and live birth rates after vitrification of in vitro matured oocytes.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06157619 (Vitrification of In Vitro Matured Oocytes Following the CAPA-IVM Methodology), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitrification of In Vitro Matured Oocytes Following the CAPA-IVM Methodology
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Fresh embryo transfer versus freeze-only after in vitro maturation with a pre-maturation step in women with high antral follicle count: a randomized controlled pilot study.Journal of assisted reproduction and genetics · 2021Trial
- Impact of Maturation and Vitrification Time of Human GV Oocytes on the Metaphase Plate Configuration.International journal of molecular sciences · 2021Trial
- Ethical considerations and management strategies for fertility preservation in women of reproductive age with malignant tumors: Chinese practices and perspectives.Frontiers in endocrinology · 2026Review
- Fertility in young-onset colorectal patients with cancer: a review.The oncologist · 2024Review
- Mature oocyte found during ovarian tissue cryopreservation in an early adolescent female.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Metformin alleviates cryoinjuries in porcine oocytes by reducing membrane fluidity through the suppression of mitochondrial activity.Communications biology · 2024Article
- [Reproductive Strategies for Declining Fertility: Fertility Preservation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Oocyte cryopreservation with in vitro maturation for fertility preservation in girls at risk for ovarian insufficiency.Journal of assisted reproduction and genetics · 2023Article
- In vitro maturation (IVM) of human immature oocytes: is it still relevant?Reproductive biology and endocrinology : RB&E · 2023Review
- Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview.Journal of clinical medicine · 2023Review
- Fertility-sparing options for cancer patients.Abdominal radiology (New York) · 2023Review
- Potential Development of Vitrified Immature Human Oocytes: Influence of the Culture Medium and the Timing of Vitrification.International journal of molecular sciences · 2022Article
- Fertility preservation strategies for cancerous women: An updated review.Turkish journal of obstetrics and gynecology · 2022Article
- Immature Oocyte for Fertility Preservation.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess effects on fertilization rate, embryo quality, pregnancy, and live birth rates of vitrification and warming of oocytes that matured in vitro (vIVM) compared to fresh in vitro maturation (fIVM) cycles.
methodsA retrospective cohort study conducted at a university hospital-affiliated IVF unit. Fifty-six cycles of vIVM cycles and 263 fIVM in women diagnosed with polycystic ovarian syndrome (PCOS) ovaries were included in the analysis. The study group included PCOS patients who failed ovulation induction with intrauterine insemination and were offered IVM cycle followed by oocyte vitrification and warming. The embryological aspects and clinical outcomes were compared to those of controls undergoing fresh IVM cycles during the same period. The main outcome measure was live birth rate.
resultsOne thousand seventy oocytes were collected from 56 patients and underwent vitrification and warming. In the control group, 4781 oocytes were collected from 219 patients who had undergone a fresh IVM cycle. Oocyte maturation rates were similar between the groups (mean ± SD: 0.7 ± 0.2 vs. 0.6 ± 0.2, for vIVM and fIVM, respectively). Survival rate after warming was 59.8%. Fertilization and embryo cleavage rates per oocyte were significantly lower in the vIVM group. Clinical pregnancy (10.7 vs. 36.1%) and live birth rates (8.9 vs. 25.9%) per cycle were significantly lower in the vIVM group than those in the fIVM group (P = 0.005 and P < 0.001, respectively). Five healthy babies were born in the vIVM group.
conclusionsThe reproductive potential of vitrified IVM oocytes is impaired. This injury likely occurs through vitrification and warming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.