ReviewJournal of inherited metabolic disease2018
Metabolism of amino acid neurotransmitters: the synaptic disorder underlying inherited metabolic diseases.
Review in Journal of inherited metabolic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
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- Impact of long-term nitrogen scavenger therapy on clinical outcome in individuals with urea cycle disorders.Scientific reports · 2026Article
- Changes in the Amino Acid Composition of Bee-Collected Pollen During 15 Months of Storage in Fresh-Frozen and Dried Forms.Foods (Basel, Switzerland) · 2026Article
- Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study.Psychopharmacology · 2026Article
- Hemozoin induces neuronal injury primarily characterized by axon rupture and mitochondrial damage in experimental cerebral malaria.Parasites & vectors · 2025Article
- α-Methyltryptophan mitigates cognitive impairment in db/db mice: involvement of gut-brain metabolic remodeling.Nutrition & metabolism · 2025Article
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- Exposure to the plasticizer dibutyl phthalate causes oxidative stress and neurotoxicity in brain tissue.Environmental science and pollution research international · 2024Article
- Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Review
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders.Combinatorial chemistry & high throughput screening · 2024Review
- Chemotherapy-Induced Peripheral Neuropathy.Handbook of experimental pharmacology · 2023Article
- Hematological Changes in Sika Doe and Suckling Fawn Fed with Spent Mushroom Substrate ofAnimals : an open access journal from MDPI · 2022Article
- Neurotransmitters-Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System.International journal of molecular sciences · 2022Review
- A culture model for the assessment of phenylalanine neurotoxicity in phenylketonuria.In vitro models · 2022Article
- Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.International journal of molecular sciences · 2022Review
- Multi-Omics Analysis Reveals Aberrant Gut-Metabolome-Immune Network in Schizophrenia.Frontiers in immunology · 2022Article
- The CBInternational journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amino acids are involved in various metabolic pathways and some of them also act as neurotransmitters. Since biosynthesis of L-glutamate and γ-aminobutyric acid (GABA) requires 2-oxoglutarate while 3-phosphoglycerate is the precursor of L-glycine and D-serine, evolutionary selection of these amino acid neurotransmitters might have been driven by their capacity to provide important information about the glycolytic pathway and Krebs cycle. Synthesis and recycling of amino acid neurotransmitters as well as composition and function of their receptors are often compromised in inherited metabolic diseases. For instance, increased plasma L-phenylalanine concentrations impair cerebral biosynthesis of protein and bioamines in phenylketonuria, while elevated cerebral L-phenylalanine directly acts via ionotropic glutamate receptors. In succinic semialdehyde dehydrogenase deficiency, the neurotransmitter GABA and neuromodulatory γ-hydroxybutyric acid are elevated. Chronic hyperGABAergic state results in progressive downregulation of GABA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.