Evidence map›Paper›PMID 29869160›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study.

Süleyman Oyan, Arzu Tatlıpınar, Beste M Atasoy, Pembegül Güneş, Dilek Özbeyli, Serhan Keskin, Ayse Dağlı Değerli

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Süleyman OyanEar Nose and Throat Clinic, Health Sciences University Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Arzu TatlıpınarEar Nose and Throat Clinic, Health Sciences University Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. arzutatli@yahoo.com.ORCID http://orcid.org/0000-0003-4098-0069
Beste M AtasoyDepartment of Radiation Oncology, Marmara University School of Medicine, Istanbul, Turkey.
Pembegül GüneşPathology Clinic, Health Sciences University Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Dilek ÖzbeyliExperimental Animal Laboratory, Marmara University School of Medicine, Istanbul, Turkey.
Serhan KeskinEar Nose and Throat Clinic, Health Sciences University Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Ayse Dağlı DeğerliClinic of Radiation Oncology, Ministry of Health-Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
Sağlık Bilimleri Üniversitesi · TRMarmara University · TRHaydarpaşa Numune Eğitim ve Araştırma Hastanesi · TRMinistry of Health · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradiation on laryngeal mucosa in rats. STUDY

designAnimal study.

settingExperimental animal laboratory, tertiary referral center. SUBJECT AND

methodTwenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination.

resultsEdema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux and irradiation and irradiation groups while pseudostratification was higher in the reflux and irradiation group.

conclusionIonizing radiation-induced inflammation may increase on previously inflammated area due to gastroesophageal reflux. Therefore, it may be helpful to investigate and treat the reflux in laryngeal cancer patients that will receive ionizing radiation.

Indexed as

AdultAnimalsDisease Models, AnimalFemaleGastroesophageal RefluxHumansLaryngeal MucosaMucous MembraneRatsRats, WistarAnimal studyGastroesophageal refluxInflammationIonizing radiationLarynx

Identifiers

PMID29869160
OpenAlexW2807517875

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.