Evidence map›Paper›PMID 29869117›Full record

ArticlePediatric nephrology (Berlin, Germany)2018

Validating the use of bioimpedance spectroscopy for assessment of fluid status in children.

Indranil Dasgupta, David Keane, Elizabeth Lindley, Ihab Shaheen, Kay Tyerman, Franz Schaefer, Elke Wühl, Manfred J Müller, Anja Bosy-Westphal, Hans Fors and 4 more

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
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  11. Evaluation of Hypervolemia in Children.Journal of pediatric intensive care · 2021
    Review
  12. Article
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  14. Article
  15. Total body water measurement in childhood.Pediatric nephrology (Berlin, Germany) · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Indranil DasguptaHeartlands Hospital and University of Birmingham, Birmingham, UK. Indranil.Dasgupta@heartofengland.nhs.uk.
David KeaneDepartments of Renal Medicine and Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Elizabeth LindleyDepartments of Renal Medicine and Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Ihab ShaheenDepartment of Children's Nephrology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Kay TyermanDepartment of Children's Nephrology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Franz SchaeferPediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.
Elke WühlPediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.
Manfred J MüllerInstitute for Human Nutrition and Food Science, Christian-Albrecht University, Kiel, Germany.
Anja Bosy-WestphalUniversität Hohenheim, Hohenheim, Germany.
Hans ForsDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Jovanna DahlgrenDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Paul ChamneyGlobal R&D, Fresenius Medical Care, Bad Homburg, Germany.
Peter WabelGlobal R&D, Fresenius Medical Care, Bad Homburg, Germany.
Ulrich MoisslGlobal R&D, Fresenius Medical Care, Bad Homburg, Germany.
Leeds Teaching Hospitals NHS Trust · GBFresenius Medical Care (Germany) · DEUniversity Hospital Heidelberg · DEUniversity of Gothenburg · SEChristian-Albrechts-Universität zu Kiel · DEHeartlands Hospital · GBUniversity of Hohenheim · DE

Funding

Medical Research Council MC_UP_A090_1005
6 · The paper itself

Abstract

backgroundBioimpedance spectroscopy (BIS) with a whole-body model to distinguish excess fluid from major body tissue hydration can provide objective assessment of fluid status. BIS is integrated into the Body Composition Monitor (BCM) and is validated in adults, but not children. This study aimed to (1) assess agreement between BCM-measured total body water (TBW) and a gold standard technique in healthy children, (2) compare TBW_BCM with TBW from Urea Kinetic Modelling (UKM) in haemodialysis children and (3) investigate systematic deviation from zero in measured excess fluid in healthy children across paediatric age range.

methodsTBW_BCM and excess fluid was determined from standard wrist-to-ankle BCM measurement. TBW_D2O was determined from deuterium concentration decline in serial urine samples over 5 days in healthy children. UKM was used to measure body water in children receiving haemodialysis. Agreement between methods was analysed using paired t test and Bland-Altman method comparison.

resultsIn 61 healthy children (6-14 years, 32 male), mean TBW_BCM and TBW_D2O were 21.1 ± 5.6 and 20.5 ± 5.8 L respectively. There was good agreement between TBW_BCM and TBW_D2O (R

conclusionsThese results suggest BCM can be used in children as young as 2 years to measure normally hydrated weight and assess fluid status.

Indexed as

Electric ImpedanceAdolescentBody CompositionBody WaterChildChild, PreschoolDeuteriumFemaleHealthy VolunteersHumansKidney Failure, ChronicMaleMonitoring, PhysiologicRenal DialysisWater-Electrolyte ImbalanceDeuteriumBioimpedanceChildrenChronic kidney diseaseFluid volumeHaemodialysisOverhydrationTotal body water

Identifiers

PMID29869117
PMCPMC6061658
OpenAlexW2806465775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.