Evidence map›Paper›PMID 29869061›Full record

ArticleMolecular imaging and biology2019

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[

Dewei Tang, Jun Li, Michael L Nickels, Gang Huang, Allison S Cohen, H Charles Manning

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. TSPO Radioligands for Neuroinflammation: An Overview.Molecules (Basel, Switzerland) · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Preclinical and clinical study on [European journal of nuclear medicine and molecular imaging · 2022
    Article
  8. Review
  9. Imaging of the glioma microenvironment by TSPO PET.European journal of nuclear medicine and molecular imaging · 2021
    Review
  10. Review
  11. Article
  12. TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dewei TangCenter for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Jun LiVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael L NickelsVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Gang HuangCenter for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Allison S CohenVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
H Charles ManningVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA. henry.c.manning@vanderbilt.edu.

Funding

Vanderbilt In Vivo Cellular and Molecular Imaging CenterP50CA128323 · NCI · VANDERBILT UNIVERSITY · PI PHAM, WELLINGTON · 2008 to 2012
$6.8M
TSPO Ligands for Cancer ImagingR01CA163806 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2012 to 2016
$2.2M
South-Eastern Center for Imaging Animal Models of CancerU24CA126588 · NCI · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2007 to 2011
$2.1M
Synergizing Quantitative HTS Technologies to Guide MIA Discovery and DevelopmentK25CA127349 · NCI · VANDERBILT UNIVERSITY · PI MANNING, HENRY CHARLES · 2008 to 2012
$709k
Small Animal PET ScannerS10RR017858 · NCRR · VANDERBILT UNIVERSITY · PI KESSLER, ROBERT MICHAEL · 2003 to 2003
$500k
NCI NIH HHS K25 CA127349NCI NIH HHS P50 CA128323NCI NIH HHS R01 CA163806NCI NIH HHS U24 CA126588NCRR NIH HHS S10 RR017858
6 · The paper itself

Abstract

purposeThere is an urgent need for the development of novel positron emission tomography (PET) tracers for glioma imaging. In this study, we developed a novel PET probe ([ PROCEDURES: In this study, we synthesized [

resultsCompared to previously reported TSPO tracers including [

conclusionsThese studies illustrate that [

Indexed as

AnimalsBrain NeoplasmsCarrier ProteinsDisease ProgressionDrug Evaluation, PreclinicalFluorine RadioisotopesGliomaLigandsMagnetic Resonance ImagingMalePositron-Emission TomographyPyrazolesPyrimidinesRatsRats, WistarReceptors, GABA-ACarrier ProteinsFluorine-18Fluorine RadioisotopesLigandsN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptors, GABA-ATspo protein, ratCancer imagingDPA-714GliomaMolecular imagingPETTSPOVUIIS1018A

Identifiers

PMID29869061
PMCPMC6953265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.