Evidence map›Paper›PMID 29868977›Full record

ArticleAnnals of surgical oncology2018

Role of Additional Organ Resection in Adrenocortical Carcinoma: Analysis of 167 Patients from the U.S. Adrenocortical Carcinoma Database.

Paula Marincola Smith, Colleen M Kiernan, Thuy B Tran, Lauren M Postlewait, Shishir K Maithel, Jason Prescott, Timothy Pawlik, Tracy S Wang, Jason Glenn, Ioannis Hatzaras and 17 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 15 institutions in 1 country.

Paula Marincola SmithDivision of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 597 Preston Research Building 2220 Pierce Ave, Nashville, TN, 37232, USA.
Colleen M KiernanDivision of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 597 Preston Research Building 2220 Pierce Ave, Nashville, TN, 37232, USA.
Thuy B TranStanford University School of Medicine, Stanford, CA, USA.
Lauren M PostlewaitDivision of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Shishir K MaithelDivision of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Jason PrescottThe Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timothy PawlikThe Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tracy S WangMedical College of Wisconsin, Milwaukee, WI, USA.
Jason GlennMedical College of Wisconsin, Milwaukee, WI, USA.
Ioannis HatzarasNew York University School of Medicine, New York, NY, USA.
Rivka ShenoyNew York University School of Medicine, New York, NY, USA.
John PhayDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Lawrence A ShirleyDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Ryan C FieldsBarnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Linda JinBarnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Sharon WeberDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ahmed SalemDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jason SicklickDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Shady GadDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Adam YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John MansourDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Quan-Yang DuhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Natalie SeiserDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Konstantinos VotanopoulosDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Edward A LevineDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
George PoultsidesStanford University School of Medicine, Stanford, CA, USA.
Carmen C SolórzanoDivision of Surgical Oncology, Department of Surgery, Vanderbilt University Medical Center, 597 Preston Research Building 2220 Pierce Ave, Nashville, TN, 37232, USA. carmen.solorzano@vanderbilt.edu.
Vanderbilt University Medical Center · USEmory University · USMedical College of Wisconsin · USNew York University · USStanford University · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Diego · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USWake Forest University · USBarnes-Jewish Hospital · USJewish Hospital · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Surgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0M
Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
NCI NIH HHS K08 CA168999NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA106183
6 · The paper itself

Abstract

backgroundAdrenocortical carcinoma (ACC) is a rare and aggressive cancer. This report describes factors and outcomes associated with resection of extra-adrenal organs en bloc during index adrenalectomy.

methodsPatients who underwent ACC resection for non-metastatic disease from 1993 to 2014 at 13 participating institutions of the US-ACC Group were included in the study. Factors associated with en bloc resection were assessed by uni- and multivariate analysis. The primary end point was overall survival.

resultsIn this study, 167 patients were included and categorized as adrenalectomy with en bloc resection (AdEBR) if they had extra-adrenal organs removed or adrenalectomy (Ad) if they did not. The demographics were similar between the AdEBR (n = 68, 40.7%) and Ad groups, including age, gender, race, American Society of Anesthesiology (ASA) class, and body mass index (BMI). The AdEBR group had larger tumors (13 vs. 10 cm), more open operations (97.1 vs. 63.6%), and more lymph node dissections (LNDs) (36.8 vs. 12.1%). The most common organs removed were kidney (55.9%), liver (27.9%), and spleen (23.5%). Multiple organs were removed in 38.2% (n = 26) of the patients. Margin-negative resections were similar between the two groups. In the multivariate Cox regression adjusted for T and N stages, LND, margin, size, and hormone hypersecretion, en bloc resection was not associated with improved survival (hazard ratio [HR], 1.42; p = 0.323).

conclusionThe study findings validated current practice by showing that en bloc resection should occur at index adrenalectomy for ACC when a T4 lesion is suspected pre- or intraoperatively, or when it is necessary to avoid tumor rupture. However, in this study, when a negative margin resection was otherwise achieved, removal of extra-adrenal organs en bloc was not associated with additional survival benefit.

Indexed as

Databases, FactualAdrenal Cortex NeoplasmsAdrenalectomyAdrenocortical CarcinomaAdultFemaleFollow-Up StudiesHumansLymph Node ExcisionMaleMiddle AgedPrognosisRetrospective StudiesSurvival Rate

Identifiers

PMID29868977
PMCPMC6061942
OpenAlexW2805440537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.