Trial reportIntensive care medicine2018
Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.
Trial report in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026.Intensive care medicine · 2026Pooled it
- Association of Arterial Hyperoxia With Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2021Pooled it
- Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT.Health technology assessment (Winchester, England) · 2026Trial
- High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs.Health technology assessment (Winchester, England) · 2025Trial
- Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial.Critical care (London, England) · 2019Trial
- The Paediatric Intensive Care Adaptive Platform Trial (PIVOTAL): Turning Pediatric Critical Care Practice Into Clinical Research.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Article
- Parent perspectives on neonatal research without prior consent: a mixed-methods interview study.BMC medical ethics · 2026Article
- Partial waiver of consent to overcome translational science barriers in neonatal clinical research.Journal of clinical and translational science · 2025Article
- Article
- Chest Physiotherapy for Mechanically Ventilated Children: A Systematic Review.Journal of pediatric intensive care · 2024Review
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.Clinics in perinatology · 2024Review
- Closed-loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study.Frontiers in medicine · 2024Article
- Oxygen saturation targets for children with respiratory distress: a systematic review.ERJ open research · 2023Review
- Implication of the 2014 World Health Organization Integrated Management of Childhood Illness Pneumonia Guidelines with and without pulse oximetry use in Malawi: A retrospective cohort study.Gates open research · 2023Article
- State-of-the-art management of the acutely unwell child.Anaesthesia · 2022Review
- Insisting on prospective consent in paediatric critical care research may be throwing the baby out with the bathwater.Journal of paediatrics and child health · 2022Article
- Closed-loop oxygen control improves oxygenation in pediatric patients under high-flow nasal oxygen-A randomized crossover study.Frontiers in medicine · 2022Article
- A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients.Journal of the Intensive Care Society · 2021Article
- Perceptions of Hyperoxemia and Conservative Oxygen Therapy in the Management of Acute Respiratory Failure.Annals of the American Thoracic Society · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOxygen saturation monitoring for children receiving respiratory support is standard worldwide. No randomised clinical trials have compared peripheral oxygen saturation (SpO
methodsWe undertook an open, parallel-group randomised trial of children > 38 weeks completed gestation and < 16 years of age receiving invasive or non-invasive respiratory support and supplemental oxygen who were admitted urgently to one of three paediatric intensive care units. A 'research without prior consent' approach was employed. Children were randomly assigned to a liberal oxygenation group (SpO
resultsA total of 159 children met the inclusion criteria, of whom 119 (75%) were randomised between April and July 2017, representing a rate of 10 patients per month per site. The mean time to randomisation from first contact with an intensive care team was 1.9 (SD 2.2) h. Consent to continue in the study was obtained in 107 cases (90%); the children's parents/legal representatives were supportive of the consent process. The median (interquartile range, IQR) of time-weighted individual mean SpO
conclusionA definitive clinical trial of peripheral oxygen saturation targets is feasible in critically ill children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.