ReviewJAMA neurology2018
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Review in JAMA neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 294 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Telemedicine on Health Outcomes (Clinical, Humanistic, Economic) in the Management of Patients With Functional Motor Disorder: Randomised Controlled Clinical Trial
Implementing a Digital Telerehabilitation Protocol and Non-motor Outcomes, and Quality of Life in Patients With Functional Motor Disorders: a Feasibility 2-arm Parallel Randomized Controlled Clinical Trial
Who cites it
294 citing papers in PubMed, 8 syntheses or guidelines pooled it, 721 citations in OpenAlex.
- (Es)ketamine in functional neurological disorder: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Consequences of Acute Presentations of Functional Neurological Disorders in Neuro-Oncology Patients: Case Series and Systematic Review.Brain and behavior · 2025Pooled it
- Atypical Symptoms Following Concussion: A Comprehensive Review of Functional Deficits.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Pooled it
- Treatment of functional neurological disorder: an umbrella review of systematic reviews and meta-analyses.Journal of neurology · 2025Pooled it
- Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders.Psychiatry and clinical neurosciences · 2024Pooled it
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Pooled it
- Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap.Journal of neurology · 2022Pooled it
- Nocebo Hypothesis Cognitive Behavioral Therapy for Functional Neurological Symptom Disorder (Motor Type): A Pilot Randomized Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Epidemiology and clinical features of movement disorders in a Mexican Mestizo cohort: a 10-year tertiary-center study.Arquivos de neuro-psiquiatria · 2026Article
- Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Neurofeedback for functional neurological disorders: future directions for research and clinical practice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Functional Neurological Symptom Disorder Obscured by Incomplete Diagnostic Communication: A Case Report.Cureus · 2026Article
- Functional neurological disorder: characterization, diagnosis, and outcome predictors in a Brazilian cohort.Arquivos de neuro-psiquiatria · 2026Article
- Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Implementation of bedside and intraoperative neurophysiological monitoring in the diagnosis of functional neurological symptom disorder following spinal surgery: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Multimodal assessment of clinical and neural changes following multidisciplinary management in functional motor disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The oxytocinergic system in functional neurological disorder: Preliminary testing of associations with interoception and childhood trauma.Comprehensive psychoneuroendocrinology · 2026Article
- Article
- Article
234 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 11 institutions in 5 countries.
Funding
Abstract
Importance: Functional neurological disorders (FND) are common sources of disability in medicine. Patients have often been misdiagnosed, correctly diagnosed after lengthy delays, and/or subjected to poorly delivered diagnoses that prevent diagnostic understanding and lead to inappropriate treatments, iatrogenic harm, unnecessary and costly evaluations, and poor outcomes. Observations: Functional Neurological Symptom Disorder/Conversion Disorder was adopted by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, replacing the term psychogenic with functional and removing the criterion of psychological stress as a prerequisite for FND. A diagnosis can now be made in an inclusionary manner by identifying neurological signs that are specific to FNDs without reliance on presence or absence of psychological stressors or suggestive historical clues. The new model highlights a wider range of past sensitizing events, such as physical trauma, medical illness, or physiological/psychophysiological events. In this model, strong ideas and expectations about these events correlate with abnormal predictions of sensory data and body-focused attention. Neurobiological abnormalities include hypoactivation of the supplementary motor area and relative disconnection with areas that select or inhibit movements and are associated with a sense of agency. Promising evidence has accumulated for the benefit of specific physical rehabilitation and psychological interventions alone or in combination, but clinical trial evidence remains limited. Conclusions and Relevance: Functional neurological disorders are a neglected but potentially reversible source of disability. Further research is needed to determine the dose and duration of various interventions, the value of combination treatments and multidisciplinary therapy, and the therapeutic modality best suited for each patient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.