Evidence map›Paper›PMID 29868707›Full record

ArticleAmerican journal of clinical pathology2018

Detection of BRAF V600E Mutations With Next-Generation Sequencing in Infarcted Thyroid Carcinomas After Fine-Needle Aspiration.

Erik Kouba, Andrew Ford, Charmaine G Brown, Chen Yeh, Gene P Siegal, Upender Manne, Isam-Eldin Eltoum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Erik KoubaDepartment of Pathology, University of Alabama-Birmingham, Birmingham, AL.
Andrew FordCirculogene, Birmingham, AL.
Charmaine G BrownCirculogene, Birmingham, AL.
Chen YehCirculogene, Birmingham, AL.
Gene P SiegalDepartment of Pathology, University of Alabama-Birmingham, Birmingham, AL.
Upender ManneDepartment of Pathology, University of Alabama-Birmingham, Birmingham, AL.
Isam-Eldin EltoumDepartment of Pathology, University of Alabama-Birmingham, Birmingham, AL.
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
NCI NIH HHS P30 CA013148
6 · The paper itself

Abstract

objectivesFine-needle aspiration (FNA) of thyroid lesions may result in infarction and diagnostic difficulties on subsequent thyroidectomy specimens. Next-generation sequencing (NGS) methods for detection of hallmark driver BRAF V600E mutations may help characterize such tumors in which histologic alterations preclude definitive tissue diagnosis.

methodsThyroidectomy specimens with both malignant FNA diagnoses and resultant infarction were identified from our institutional database. NGS methods were used to detect BRAF V600E mutations in the infarcted thyroid carcinomas.

resultsNine thyroid carcinomas with infarction were characterized as BRAF-like papillary thyroid carcinoma based on molecular driver categorization and histologic diagnosis. BRAF V600E mutations were detected in the infarcted tissue in four (67%) of six lesions.

conclusionsWe demonstrate detection of hallmark BRAF V600E mutations by NGS within infarcted tissue of thyroid carcinomas after FNA. This suggests a potential ancillary method of characterizing infarcted thyroid carcinomas whose altered histology may be nondiagnostic.

Indexed as

AgedAged, 80 and overBiopsy, Fine-NeedleDNA Mutational AnalysisFemaleHigh-Throughput Nucleotide SequencingHumansInfarctionMaleMiddle AgedMutationProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID29868707
PMCPMC8482970
OpenAlexW2807693816

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.