Evidence map›Paper›PMID 29868599›Full record

ReviewFrontiers in nutrition2018

Time to Optimize Supplementation: Modifying Factors Influencing the Individual Responses to Extracellular Buffering Agents.

André B Heibel, Pedro H L Perim, Luana F Oliveira, Lars R McNaughton, Bryan Saunders

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07737327 (The Acute Effects of Individually Timed Sodium Citrate Ingestion on Repeated Sprint Performance in Professional Female Soccer Players), which is not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07737327 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Acute Effects of Individually Timed Sodium Citrate Ingestion on Repeated Sprint Performance in Professional Female Soccer Players: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled20ConditionsExercise-Induced Fatigue, Athletic Performance, SoccerArmsSodium Citrate Oral Product, Placebo
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  16. Caffeine and sodium bicarbonate supplementation alone or together improve karate performance.Journal of the International Society of Sports Nutrition · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

André B HeibelApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Pedro H L PerimApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Luana F OliveiraApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
Lars R McNaughtonSports Nutrition and Performance Group, Department of Sport and Physical Activity, Edge Hill University, Ormskirk, United Kingdom.
Bryan SaundersApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood alkalosis, as indicated by an increased blood bicarbonate concentration and pH, has been shown to be beneficial for exercise performance. Sodium bicarbonate, sodium citrate, and sodium or calcium lactate, can all result in increased circulating bicarbonate and have all independently been shown to improve exercise capacity and performance under various circumstances. Although there is considerable evidence demonstrating the efficacy of these supplements in several sports-specific situations, it is commonly acknowledged that their efficacy is equivocal, due to contrasting evidence. Herein, we discuss the physiological and environmental factors that may modify the effectiveness of these supplements including, (i) absolute changes in circulating bicarbonate; (ii) supplement timing, (iii) the exercise task performed, (iv) monocarboxylate transporter (MCT) activity; (v) training status, and (vi) associated side-effects. The aim of this narrative review is to highlight the factors which may modify the response to these supplements, so that individuals can use this information to attempt to optimize supplementation and allow the greatest possibility of an ergogenic effect.

Indexed as

alkalosisbicarbonatebuffering agentscitratelactate

Identifiers

PMID29868599
PMCPMC5951986

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.