ArticleFrontiers in cellular and infection microbiology2018
Identification and Validation of an Antivirulence Agent Targeting HlyU-Regulated Virulence in
Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Acetylome Analysis inPathogens (Basel, Switzerland) · 2026Article
- Review
- Attenuation of a DNA cruciform by a conserved regulator directs T3SS1 mediated virulence in Vibrio parahaemolyticus.Nucleic acids research · 2023Article
- Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation inbioRxiv : the preprint server for biology · 2023Article
- Biosynthesis of Gold Nanoparticles and Its Effect againstMolecules (Basel, Switzerland) · 2022Article
- Targeting Virulence Genes Expression inInternational journal of molecular sciences · 2022Article
- Roles of Two-Component Systems inInternational journal of molecular sciences · 2021Review
- Microbial Genomics as a Catalyst for Targeted Antivirulence Therapeutics.Frontiers in medicine · 2021Article
- Spatiotemporal Regulation ofToxins · 2020Review
- The role of Vibrio vulnificus virulence factors and regulators in its infection-induced sepsis.Folia microbiologica · 2020Review
- Genome-Wide Analysis ofFrontiers in microbiology · 2020Article
- Review
- Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species.Scientific reports · 2019Article
- Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition inFrontiers in microbiology · 2019Article
- Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors inFrontiers in microbiology · 2019Article
- Identification of 2',4'-Dihydroxychalcone as an Antivirulence Agent Targeting HlyU, a Master Virulence Regulator inMolecules (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance (AMR) in pathogens is the result of indiscriminate use of antibiotics and consequent metabolic/genetic modulation to evolve survival strategies and clonal-selection in AMR strains. As an alternative to antibiotic treatment, antivirulence strategies are being developed, not only to combat bacterial pathogenesis, but also to avoid emerging antibiotic resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.