Evidence map›Paper›PMID 29868502›Full record

ArticleFrontiers in cellular and infection microbiology2018

Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Mediated

Rui Cruz, Isabel Pereira-Castro, Maria T Almeida, Alexandra Moreira, Didier Cabanes, Sandra Sousa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Toxins · 2020
    Article
  4. Article
  5. Article
  6. Microbiology spectrum · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rui CruzGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Isabel Pereira-CastroGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Maria T AlmeidaGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Alexandra MoreiraGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Didier CabanesGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Sandra SousaGroup of Molecular Microbiology, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTInstituto de Biologia Molecular e CelularUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host cytoskeleton is a major target for bacterial pathogens during infection. In particular, pathogens usurp the actin cytoskeleton function to strongly adhere to the host cell surface, to induce plasma membrane remodeling allowing invasion and to spread from cell to cell and disseminate to the whole organism. Keratins are cytoskeletal proteins that are the major components of intermediate filaments in epithelial cells however, their role in bacterial infection has been disregarded. Here we investigate the role of the major epithelial keratins, keratins 8 and 18 (K8 and K18), in the cellular infection by

Indexed as

Signal TransductionActin CytoskeletonBacterial ProteinsCaco-2 CellsCadherinsEpithelial CellsGene ExpressionHeLa CellsHumansIntegrin beta1KeratinsListeria monocytogenesListeriosisMembrane ProteinsProto-Oncogene Proteins c-metRNA, MessengerBacterial ProteinsCadherinsinlB protein, Listeria monocytogenesInlE protein, Listeria monocytogenesIntegrin beta1internalin protein, BacteriaKeratinsMembrane ProteinsMET protein, humanProto-Oncogene Proteins c-metRNA, MessengerRNA, Small Interferingcellular infectioncMet signalinggene expressionintermediate filamentskeratinsListeria monocytogenesmRNA stability

Identifiers

PMID29868502
PMCPMC5960701
OpenAlexW2802719861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.