Evidence map›Paper›PMID 29868491›Full record

ArticleFrontiers in cellular and infection microbiology2018

M Protein of Group a Streptococcus Plays an Essential Role in Inducing High Expression of A20 in Macrophages Resulting in the Downregulation of Inflammatory Response in Lung Tissue.

Cuiqing Ma, Xue Gao, Shuhui Wu, Ling Zhang, Jiachao Wang, Zhengzheng Zhang, Zhiyan Yao, Xiaotian Song, Wenjian Li, Xiurong Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cuiqing MaKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Xue GaoKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Shuhui WuDepartment of Microbiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, China.
Ling ZhangKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Jiachao WangKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Zhengzheng ZhangKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Zhiyan YaoKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Xiaotian SongKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Wenjian LiKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Xiurong WangKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Huidong FengKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Lin WeiKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, China.
Hebei Medical University · CNHebei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group A streptococcus (GAS), a common pathogen, is able to escape host immune attack and thus survive for longer periods of time. One of the mechanisms used by GAS is the upregulated expression of immunosuppressive molecules, which leads to a reduction in the production of inflammatory cytokines in immune cells. In the present study, we found that macrophages produced lower levels of proinflammatory cytokines (IL-1β, TNF-α, IL-6) when challenged with GAS than they did when challenged with

Indexed as

AnimalsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsDisease Models, AnimalEscherichia coliFemaleHumansInterleukin-1betaInterleukin-6LungMacrophagesMiceMice, Inbred C57BLPneumonia, PneumococcalRAW 264.7 CellsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsInterleukin-1betaInterleukin-6streptococcal M proteinTnfaip3 protein, mouseTumor Necrosis Factor-alphaTumor Necrosis Factor alpha-Induced Protein 3A20Group A Streptococcus (GAS)macrophagesM proteinnegative regulation

Identifiers

PMID29868491
PMCPMC5968387
OpenAlexW2797822870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.