Evidence map›Paper›PMID 29868478›Full record

ArticleFrontiers in oncology2018

Discovery of Novel and Clinically Relevant Markers in Formalin-Fixed Paraffin-Embedded Esophageal Cancer Specimen.

Joe Abdo, Christopher S Wichman, Nicholas E Dietz, Pawel Ciborowski, John Fleegel, Sumeet K Mittal, Devendra K Agrawal

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. CAR T-Cell Therapy in Cancer: Balancing Efficacy with Cardiac Toxicity Concerns.Journal of cancer science and clinical therapeutics · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joe AbdoDepartment of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
Christopher S WichmanDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States.
Nicholas E DietzDepartment of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
Pawel CiborowskiDepartment of Pharmacology, University of Nebraska Medical Center, Omaha, NE, United States.
John FleegelDepartment of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
Sumeet K MittalDepartment of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
Devendra K AgrawalDepartment of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
Creighton University · USUniversity of Nebraska Medical Center · USCHI Health · US

Funding

EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSISR01HL120659 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2013 to 2017
$3.6M
VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASER01HL116042 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2012 to 2016
$3.3M
GENE AND STEM CELL THERAPY IN CORONARY ARTERY BYPASS GRAFTR01HL128063 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2015 to 2018
$2.9M
NHLBI NIH HHS R01 HL116042NHLBI NIH HHS R01 HL120659NHLBI NIH HHS R01 HL128063
6 · The paper itself

Abstract

Due to the ineffectiveness of chemoradiation and targeted therapy in esophageal anticancer care and the subsequent low survival rates, we constructed a high throughput method to discover and investigate new markers with prognostic, diagnostic, and therapeutic clinical utility. This was accomplished by developing a quick, inexpensive, and dependable platform to simultaneously quantify thousands of proteins which subsequently revealed novel markers involved in the pathogenesis of esophageal adenocarcinoma (EAC)

Indexed as

chemoresistance markersformalin-fixed paraffin-embedded tissuemass spectrometrymolecular oncologyproliferation markersproteomicsSWATH analysis

Identifiers

PMID29868478
PMCPMC5954028
OpenAlexW2803005799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.