Evidence map›Paper›PMID 29868449›Full record

Trial reportNeuroImage. Clinical2018

Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.

Jian Kong, Zengjian Wang, Jaclyn Leiser, Domenic Minicucci, Robert Edwards, Irving Kirsch, Ajay D Wasan, Courtney Lang, Jessica Gerber, Siyi Yu and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  12. Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jian KongDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA. Electronic address: kongj@nmr.mgh.harvard.edu.
Zengjian WangDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Jaclyn LeiserDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Domenic MinicucciDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Robert EdwardsDepartment of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Irving KirschProgram in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ajay D WasanDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Courtney LangDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Jessica GerberMGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Siyi YuDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Vitaly NapadowMGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Ted J KaptchukProgram in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Randy L GollubDepartment of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Funding

The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0M
An fMRI study of expectancy on acupuncture treatment outcomes in knee OAR01AT005280 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, KAPTCHUK, TED · 2010 to 2014
$3.9M
Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
The Neurobiology of Placebo and Nocebo Effects: A Brain Imaging StudyR01AT006364 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2011 to 2015
$3.6M
Mentoring and Research in Placebo Studies, Asian Medicine, and CAMK24AT004095 · NCCIH · HARVARD MEDICAL SCHOOL · PI KAPTCHUK, TED · 2007 to 2016
$1.4M
Mechanistic Studies on video guided acupuncture imagery treatment of painR61AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$845k
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS K24 AT004095NCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT005280NCCIH NIH HHS R01 AT006364NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707NCCIH NIH HHS R61 AT009310
6 · The paper itself

Abstract

Objectives: Expectation can significantly modulate pain and treatment effects. This study aims to investigate if boosting patients' expectancy can enhance the treatment of knee osteoarthritis (KOA), and its underlying brain mechanism. Methods: Seventy-four KOA patients were recruited and randomized to three groups: boosted acupuncture (with a manipulation to enhance expectation), standard acupuncture, or treatment as usual (TAU). Each patient underwent six treatments before being debriefed, and four additional treatments after being debriefed. The fMRI scans were applied during the first and sixth treatment sessions. Results: We found significantly decreased knee pain in the boosted acupuncture group compared to the standard acupuncture or TAU groups after both six and ten treatments. Resting state functional connectivity (rsFC) analyses using the nucleus accumbens (NAc) as the seed showed rsFC increases between the NAc and the medial prefrontal cortex (MPFC)/rostral anterior cingulate cortex (rACC) and dorsolateral prefrontal cortex in the boosted group as compared to the standard acupuncture group after multiple treatments. Expectancy scores after the first treatment were significantly associated with increased NAc-rACC/MPFC rsFC and decreased knee pain following treatment. Conclusions: Our study provides a novel method and mechanism for boosting the treatment of pain in patients with KOA. Our findings may shed light on enhancing outcomes of pharmacological and integrative medicines in clinical settings.

Indexed as

Osteoarthritis, KneeAcupuncture TherapyAdultAgedAnalysis of VarianceBrainFemaleHumansHyperalgesiaImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPainPain MeasurementOxygenAcupunctureExpectancyKnee osteoarthritisResting state functional connectivityReward

Identifiers

PMID29868449
PMCPMC5984593

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.