ArticleNeuroImage. Clinical2017
Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer's Disease.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- The Importance of Studying the Cognitive Neuroscience of Aging Across Cultures.Annals of the New York Academy of Sciences · 2026Review
- Ancestry-specific effects ofmedRxiv : the preprint server for health sciences · 2026Article
- Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition.Ageing research reviews · 2024Review
- Examining racial differences in the network structure and properties of specific cognitive domains among older adults.GeroScience · 2024Article
- Leveraging African American family connectors for Alzheimer's disease genomic studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Biomarkers of Alzheimer's disease in Black and/or African American Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.Neurobiology of aging · 2023Article
- Quantification of race/ethnicity representation in Alzheimer's disease neuroimaging research in the USA: a systematic review.Communications medicine · 2023Review
- Identifying sex-specific risk architectures for predicting amyloid deposition using neural networks.NeuroImage · 2023Article
- Health disparities in aging: Improving dementia care for Black women.Frontiers in aging neuroscience · 2023Article
- Plasma amyloid-β42/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease.Brain communications · 2023Article
- Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults.JAMA neurology · 2023Article
- The methodology of the Agile Nudge University.Frontiers in health services · 2023Article
- Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Article
- Associations of deformation-based brain morphometry with cognitive level and decline within older Blacks without dementia.Neurobiology of aging · 2022Article
- Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age.Biomolecules · 2022Review
- Chronic Pain Severity and Sociodemographics: An Evaluation of the Neurobiological Interface.The journal of pain · 2022Observational
- Ethnoracial disparities in cognition are associated with multiple socioeconomic status-stress pathways.Cognitive research: principles and implications · 2021Article
- Measuring Resilience and Resistance in Aging and Alzheimer Disease Using Residual Methods: A Systematic Review and Meta-analysis.Neurology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
African Americans are two to four times more likely to develop dementia as Non-Hispanic Whites. This increased risk among African Americans represents a critical health disparity that affects nearly 43 million Americans. The present study tested the hypothesis that older African Americans with elevated beta-amyloid would show greater neurodegeneration (smaller hippocampal volumes and decreased cortical thickness) than older Non-Hispanic Whites with elevated beta-amyloid. Data from the Harvard Aging Brain Study (HABS) were used to form a group of older African Americans and two matched groups of Non-Hispanic White adults. Amyloid-positive African Americans had decreased cortical thickness in most of the Alzheimer's disease (AD) signature regions compared with amyloid-positive Non-Hispanic Whites. This factor was negatively correlated with age and white matter hypointensities. Using support vector regression, we also found some evidence that African Americans have an older "brain age" than Non-Hispanic Whites. These findings suggest that African Americans might be more susceptible to factors causing neurodegeneration, which then might accelerate the rate of a diagnosis of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.