Evidence map›Paper›PMID 29868224›Full record

ArticleGlobal health, epidemiology and genomics2017

Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot.

N Sallah, T Carstensen, K Wakeham, R Bagni, N Labo, M O Pollard, D Gurdasani, K Ekoru, C Pomilla, E H Young and 8 more

Abstract read
In one paragraph

Article in Global health, epidemiology and genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Tackling the lack of diversity in cancer research.Disease models & mechanisms · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

N SallahDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.ORCID 0000-0002-2953-5311
T CarstensenDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
K WakehamMRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda.
R BagniProtein Expression Lab, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
N LaboViral Oncology Section, Aids and Cancer Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
M O PollardDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
D GurdasaniDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
K EkoruDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
C PomillaDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
E H YoungDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
S FatumoDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
G AsikiMRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda.
A KamaliMRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda.
M SandhuDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
P KellamDepartment of Virus Genomics, Wellcome Trust Sanger Institute, Hinxton, UK.
D WhitbyViral Oncology Section, Aids and Cancer Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
I BarrosoDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
R NewtonMRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda.

Funding

CCR NIH HHS HHSN261200800001CMedical Research Council G0801566Medical Research Council G0901213Medical Research Council MR/K013491/1NCI NIH HHS HHSN261200800001EWellcome Trust
6 · The paper itself

Abstract

Epstein Barr virus (EBV) infects 95% of the global population and is associated with up to 2% of cancers globally. Immunoglobulin G (IgG) antibody levels to EBV have been shown to be heritable and associated with developing malignancies. We, therefore, performed a pilot genome-wide association analysis of anti-EBV IgG traits in an African population, using a combined approach including array genotyping, whole-genome sequencing and imputation to a panel with African sequence data. In 1562 Ugandans, we identify a variant in

Indexed as

AfricaEpstein-Barr virusgenomicsimmunityinfectious disease

Identifiers

PMID29868224
PMCPMC5870407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.