Evidence map›Paper›PMID 29868020›Full record

ArticleFrontiers in immunology2018

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release

Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. High Extracellular KEuropean journal of immunology · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. mBio · 2021
    Article
  8. Review
  9. Article
  10. Suppressive activity of Vδ2Cancer immunology, immunotherapy : CII · 2020
    Article
  11. Memory T Cells in Pregnancy.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Daniela LangenhorstInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Stephanie HaackInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Selina GöbInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Anna UriInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Fred LühderInstitute for Multiple Sclerosis Research and Neuroimmunology, University Medical Centre Göttingen, Göttingen, Germany.
Bernard VanhoveCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Thomas HünigInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Niklas BeyersdorfInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DEInserm · FRUniversitätsmedizin Göttingen · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred

Indexed as

AnimalsBiomarkersCD28 AntigensCD4-Positive T-LymphocytesCell DifferentiationCytokinesGATA3 Transcription FactorGene Expression RegulationHumansImmunologic MemoryImmunophenotypingLeukocytes, MononuclearLymphocyte ActivationMiceMice, TransgenicT-bet Transcription FactorBiomarkersCD28 AntigensCytokinesGATA3 protein, humanGATA3 Transcription FactorT-bet Transcription FactorT-Box Domain Proteinsantigenic recallCD28 costimulationCD4+ T helper cellscytokine secretionhumanmouseT helper 1 cells

Identifiers

PMID29868020
PMCPMC5964139
OpenAlexW2800559178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.