Evidence map›Paper›PMID 29868017›Full record

ArticleFrontiers in immunology2018

Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations.

Diego Marcos-Pérez, María Sánchez-Flores, Ana Maseda, Laura Lorenzo-López, José C Millán-Calenti, Johanna M Gostner, Dietmar Fuchs, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
    Review
  10. T lymphocyte regulatory cytokines predict frailty in older adults.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Aging and Inflammation.Cold Spring Harbor perspectives in medicine · 2024
    Review
  16. Review
  17. Article
  18. Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Diego Marcos-PérezUniversidade da Coruña, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Faculty of Education Sciences, A Coruña, Spain.
María Sánchez-FloresUniversidade da Coruña, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Faculty of Education Sciences, A Coruña, Spain.
Ana MasedaGerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, A Coruña, Spain.
Laura Lorenzo-LópezGerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, A Coruña, Spain.
José C Millán-CalentiGerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, A Coruña, Spain.
Johanna M GostnerDivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Eduardo PásaroUniversidade da Coruña, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Faculty of Education Sciences, A Coruña, Spain.
Blanca LaffonUniversidade da Coruña, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Faculty of Education Sciences, A Coruña, Spain.
Vanessa ValdiglesiasUniversidade da Coruña, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Faculty of Education Sciences, A Coruña, Spain.
Universidade da Coruña · ESInnsbruck Medical University · ATInstituto de Investigación Biomédica de A Coruña · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system may compromise its competence culminating in a chronic low-grade inflammation state. Thus, it has been proposed that frailty is associated with alterations in the concentration of pro-inflammatory molecules and in different lymphocyte subpopulations. To provide further support to the validity of that hypothesis, we conducted a cross-sectional study in a population of Spanish older adults (

Indexed as

Geriatric AssessmentLymphocyte CountLymphocyte SubsetsAgedAged, 80 and overBiomarkersComorbidityFrailtyHumansInflammation MediatorsMalePublic Health SurveillanceReference ValuesRisk FactorsROC CurveBiomarkersInflammation MediatorsC-reactive proteinfrailtyinflammaginginterleukin 6lymphocyte subpopulationssoluble TNFα receptor IItumor necrosis factor α

Identifiers

PMID29868017
PMCPMC5964167
OpenAlexW2803474895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.