Evidence map›Paper›PMID 29868002›Full record

ReviewFrontiers in immunology2018

IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View.

Achsah D Keegan, Jose Zamorano, Aleksander Keselman, Nicola M Heller

Open access · goldAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. The IL-4/IL-4R/STAT6 signaling axis regulates macrophage efferocytosis in osteoarthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
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  8. Review
  9. Article
  10. Article
  11. Review
  12. Interleukin 4/13 signaling in cardiac regeneration and repair.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  13. Review
  14. Review
  15. Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease.The Journal of allergy and clinical immunology · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Mechanisms of Dupilumab.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Achsah D KeeganDepartment of Microbiology and Immunology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, United States.
Jose ZamoranoUnidad Investigacion, Complejo Hospitalario Universitario, Caceres, Spain.
Aleksander KeselmanDepartment of Anesthesiology and Critical Care Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Nicola M HellerDepartment of Anesthesiology and Critical Care Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Complejo Hospitalario de Cáceres · ESJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Sex differences in macrophage differentiation in allergic lung inflammationR01HL124477 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HELLER, NICOLA M · 2014 to 2018
$2.0M
Role of Semaphorin 4A in Allergic InflammationR56AI122631 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KEEGAN, ACHSAH D. · 2016 to 2016
$385k
Regulation of Macrophage Activation by House Dust MiteI01BX001850 · VA · BALTIMORE VA MEDICAL CENTER · PI KEEGAN, ACHSAH D. · 2013 to 2022
–
BLRD VA I01 BX001850NHLBI NIH HHS R01 HL124477NIAID NIH HHS R56 AI122631
6 · The paper itself

Abstract

In this historical perspective, written in honor of Dr. William E. Paul, we describe the initial discovery of one of the dominant substrates for tyrosine phosphorylation stimulated by IL-4. We further describe how this "IL-4-induced phosphorylated substrate" (4PS) was characterized as a member of the insulin receptor substrate (IRS) family of large adaptor proteins that link IL-4 and insulin receptors to activation of the phosphatidyl-inositol 3' kinase pathway as well as other downstream signaling pathways. The relative contribution of the 4PS/IRS pathway to the early models of IL-4-induced proliferation and suppression of apoptosis are compared to our more recent understanding of the complex interplay between positive and negative regulatory pathways emanating from members of the IRS family that impact allergic responses.

Indexed as

Receptor, InsulinReceptors, Interleukin-13Receptors, Interleukin-4AnimalsCell DivisionHistory, 20th CenturyHistory, 21st CenturyHumansInsulinInsulin Receptor Substrate ProteinsInterleukin-13Interleukin-4MicePhosphatidylinositol 3-KinasesPhosphorylationSignal TransductionInsulinInsulin Receptor Substrate ProteinsInterleukin-13Interleukin-4IRS2 protein, humanPhosphatidylinositol 3-KinasesReceptor, InsulinReceptors, Interleukin-13Receptors, Interleukin-4TyrosineallergyIL-4-induced phosphorylated substrateinsulin receptor substrateinterleukin-13interleukin-13 receptor alpha1 subunitinterleukin-4interleukin-4 receptor αmacrophage activation

Identifiers

PMID29868002
PMCPMC5962649
OpenAlexW2804110265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.