Evidence map›Paper›PMID 29867989›Full record

ArticleFrontiers in immunology2018

PD-L1 May Mediate T-Cell Exhaustion in a Case of Early Diffuse Leishmaniasis Caused by

Daniel Holanda Barroso, Sarah De Athayde Couto Falcão, Jorgeth de Oliveira Carneiro da Motta, Laís Sevilha Dos Santos, Gustavo Henrique Soares Takano, Ciro Martins Gomes, Cecília Beatriz Fiuza Favali, Beatriz Dolabela de Lima, Raimunda Nonata Ribeiro Sampaio

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Frontiers in immunology · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. CD4Frontiers in cellular and infection microbiology · 2019
    Article
  13. Cutaneous Leishmaniasis Due toEClinicalMedicine · 2018
    Review
  14. Phenotypic and Functional Profiles of Antigen-Specific CD4Frontiers in cellular and infection microbiology · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Daniel Holanda BarrosoDermatomicology Laboratory, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Sarah De Athayde Couto FalcãoDepartment of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Jorgeth de Oliveira Carneiro da MottaInternal Medicine Department - Dermatology Service, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Laís Sevilha Dos SantosPost-Graduate Program in Medicine, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Gustavo Henrique Soares TakanoPathology Service, Hospital Universitário de Brasília, Brasília, Brazil.
Ciro Martins GomesDermatomicology Laboratory, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Cecília Beatriz Fiuza FavaliDepartment of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Beatriz Dolabela de LimaDepartment of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Raimunda Nonata Ribeiro SampaioDermatomicology Laboratory, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Universidade de Brasília · BRBrazilian Society of Tropical Medicine · BRHospital Universitário de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Diffuse cutaneous leishmaniasis (DCL) is a rare disease form associated with Case presentation: A 65-year-old DCL patient who initially failed to respond to the standard treatment for the disease showed vacuolated macrophages filled with amastigotes in lesion biopsy, and Conclusion: The dysfunctional activation of PD-L1 inhibitory pathway after

Indexed as

AgedAntigens, ProtozoanB7-H1 AntigenBiopsyCytokinesFlow CytometryGranzymesHumansInterferon-gammaLeishmaniaLeishmaniasis, CutaneousLeishmaniasis, Diffuse CutaneousMacrophagesMaleMonocytesSkinAntigens, ProtozoanB7-H1 AntigenCD274 protein, humanCytokinesGranzymesInterferon-gammadiffuse cutaneous leishmaniasisgranzyme Binterferon-gammaLeishmania (L.) amazonensisprogrammed cell death-1 ligand 1T-cell exhaustion

Identifiers

PMID29867989
PMCPMC5958277
OpenAlexW2801814228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.