Evidence map›Paper›PMID 29867976›Full record

ArticleFrontiers in immunology2018

Invariant Natural Killer T Cells Shape the Gut Microbiota and Regulate Neutrophil Recruitment and Function During Intestinal Inflammation.

Sj Shen, Kathryn Prame Kumar, Dragana Stanley, Robert J Moore, Thi Thu Hao Van, Shu Wen Wen, Michael J Hickey, Connie H Y Wong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

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  9. Frontiers in immunology · 2023
    Review
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  11. Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis.Computational and structural biotechnology journal · 2023
    Review
  12. The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments.Journal of microbiology and biotechnology · 2022
    Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sj ShenCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.
Kathryn Prame KumarCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.
Dragana StanleySchool of Health Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD, Australia.
Robert J MooreInfection and Immunity Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Thi Thu Hao VanSchool of Science, RMIT University, Melbourne, VIC, Australia.
Shu Wen WenCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.
Michael J HickeyCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.
Connie H Y WongCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.
Monash University · AUMonash Medical Centre · AURMIT University · AUCentral Queensland University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells and neutrophils play an increasingly important part in the pathogenesis of inflammatory diseases, but their precise roles in modulating colitis remain unclear. Previous studies have shown important interplays between host immune system and the gut microbiota, and the resulting modulation of inflammation. However, the interactions between iNKT cells, neutrophil and gut microbiota in regulating colitis pathology are poorly understood. Here, we show iNKT cell-deficient

Indexed as

InflammationAnimalsChemokine CXCL1Chemokine CXCL2ColitisDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeIntestinesMaleMiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsNeutrophil InfiltrationChemokine CXCL1Chemokine CXCL2Cxcl1 protein, mouseCxcl2 protein, mouseDextran Sulfatecolitisinflammationinnate immunitymucosal immunologyneutrophils

Identifiers

PMID29867976
PMCPMC5949322
OpenAlexW2801985792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.