Evidence map›Paper›PMID 29867956›Full record

ArticleFrontiers in immunology2018

VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements.

Scott Christley, Walter Scarborough, Eddie Salinas, William H Rounds, Inimary T Toby, John M Fonner, Mikhail K Levin, Min Kim, Stephen A Mock, Christopher Jordan and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Trial
  2. Article
  3. Revised Adaptive Immune Receptor Data in the Immune Epitope Database.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. AnalyzAIRR: A user-friendly guided workflow for AIRR data analysis.Immunoinformatics (Amsterdam, Netherlands) · 2025
    Article
  8. Challenges and future directions of AIRR-seq-based diagnostics.Immunoinformatics (Amsterdam, Netherlands) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Antibody repertoire sequencing analysis.Acta biochimica et biophysica Sinica · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Scott ChristleyDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Walter ScarboroughTexas Advanced Computing Center, University of Texas at Austin, Austin, TX, United States.
Eddie SalinasDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
William H RoundsDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Inimary T TobyDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
John M FonnerTexas Advanced Computing Center, University of Texas at Austin, Austin, TX, United States.
Mikhail K LevinBank of America Corporate Center, Charlotte, NC, United States.
Min KimDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Stephen A MockTexas Advanced Computing Center, University of Texas at Austin, Austin, TX, United States.
Christopher JordanTexas Advanced Computing Center, University of Texas at Austin, Austin, TX, United States.
Jared OstmeyerDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Adam BuntzmanBio5 Institute, University of Arizona, Tucson, AZ, United States.
Florian RubeltDepartment of Microbiology and Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, United States.
Marco L DavilaH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States.
Nancy L MonsonDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Richard H ScheuermannJ. Craig Venter Institute, La Jolla, CA, United States.
Lindsay G CowellDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
RepServer: Antigen Receptor Repertoire Analysis Pipelines via the WWWR01AI097403 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI COWELL, LINDSAY G. · 2012 to 2016
$3.2M
NCI NIH HHS K12 CA090625NIAID NIH HHS R01 AI097403NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation. Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison. VDJServer also provides sophisticated visualizations for exploratory analysis. It is accessible through a standard web browser Conclusion: VDJServer provides a complete analysis suite for human and mouse T-cell and B-cell receptor repertoire sequencing data. The combination of its user-friendly interface and high-performance computing allows large immune repertoire sequencing projects to be analyzed with no programming or software installation required. VDJServer is a web-accessible cloud platform that provides access through a graphical user interface to a data management infrastructure, a collection of analysis tools covering all steps in an analysis, and an infrastructure for sharing data along with workflows, results, and computational provenance. VDJServer is a free, publicly available, and open-source licensed resource.

Indexed as

Cloud ComputingAnimalsComputational BiologyComputing MethodologiesGenomicsHumansInformation DisseminationMiceSoftwareUser-Computer InterfaceVDJ ExonsWeb BrowserWorkflowB-cell receptorbioinformaticscloud computingimmune repertoireRep-seqT cell receptor

Identifiers

PMID29867956
PMCPMC5953328

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.