Evidence map›Paper›PMID 29867945›Full record

ArticleFrontiers in immunology2018

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of

Larissa Staurengo-Ferrari, Silvia C Trevelin, Victor Fattori, Daniele C Nascimento, Kalil A de Lima, Jacinta S Pelayo, Florêncio Figueiredo, Rubia Casagrande, Sandra Y Fukada, Mauro M Teixeira and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2025
    Review
  2. Bacterial and host interactions inFrontiers in microbiology · 2025
    Review
  3. Review
  4. IL-33/ST2 Axis Plays a Protective Effect inInternational journal of molecular sciences · 2021
    Article
  5. Review
  6. Review
  7. IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Article
  8. Article
  9. The Role of ST2 Receptor in the Regulation ofPathogens (Basel, Switzerland) · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Larissa Staurengo-FerrariDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Silvia C TrevelinCardiovascular Division, British Heart Foundation Centre, King's College London, London, United Kingdom.
Victor FattoriDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Daniele C NascimentoDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Kalil A de LimaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Jacinta S PelayoDepartamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Florêncio FigueiredoLaboratory of Pathology, Faculty of Medicine, University of Brasilia, Brasilia, Brazil.
Rubia CasagrandeDepartment of Pharmaceutical Sciences, Healthy Sciences Centre, Londrina State University, Londrina, Brazil.
Sandra Y FukadaDepartment of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Mauro M TeixeiraLaboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciencias Biologicas (ICB), Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Thiago M CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Foo Y LiewDivision of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Rene D OliveiraDivision of Clinical Immunology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
Paulo Louzada-JuniorDivision of Clinical Immunology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
Fernando Q CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
José C Alves-FilhoDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Waldiceu A VerriDepartamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Universidade de São Paulo · BRUniversidade Estadual de Londrina · BRBritish Heart Foundation · GBUniversidade de Brasília · BRUniversidade Federal de Minas Gerais · BRUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of ST2 deficiency in

Indexed as

AnimalsArthritis, InfectiousFemaleHumansInterferon-gammaInterleukin-1 Receptor-Like 1 ProteinInterleukin-33MaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOsteoarthritis, KneeStaphylococcal InfectionsStaphylococcus aureusSynovial FluidIL1RL1 protein, humanIl1rl1 protein, mouseIL33 protein, humanIl33 protein, mouseInterferon-gammaInterleukin-1 Receptor-Like 1 ProteinInterleukin-33interferon-γinterleukin-33M1 macrophagenitric oxideseptic arthritisST2Staphylococcus aureusTh1

Identifiers

PMID29867945
PMCPMC5968393
OpenAlexW2799935892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.