ArticleFrontiers in microbiology2018
Splenectomy Leads to Amelioration of Altered Gut Microbiota and Metabolome in Liver Cirrhosis Patients.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Splenectomy and risk of hepatocellular carcinoma.World journal of hepatology · 2025Review
- Double-Edged Sword: Urbanization and Response of Amniote Gut Microbiome in the Anthropocene.Microorganisms · 2025Review
- Characteristics of Intestinal Flora in Patients With Schistosoma japonicum Infection Undergoing Splenectomy.Parasite immunology · 2025Article
- Complete genome sequences ofMicrobiology resource announcements · 2025Article
- An Integrated Analysis of the Role of Gut Microbiome-Associated Metabolites in the Detection of MASH-Related Cirrhosis.Metabolites · 2024Article
- The gut microbiome is associated with susceptibility to febrile malaria in Malian children.Nature communications · 2024Article
- The changing metabolic landscape of bile acids - keys to metabolism and immune regulation.Nature reviews. Gastroenterology & hepatology · 2024Review
- Susceptibility to febrile malaria is associated with an inflammatory gut microbiome.Research square · 2024Article
- Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance.Cellular and molecular life sciences : CMLS · 2024Article
- A two-sample bidirectional Mendelian randomization analysis investigates associations between gut microbiota and type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Effect of intestinal microbiota transplantation on chronic hepatitis B virus infection associated liver disease.Frontiers in microbiology · 2024Article
- Intestinal flora plays a role in the progression of hepatitis-cirrhosis-liver cancer.Frontiers in cellular and infection microbiology · 2023Review
- Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- The spleen as a possible source of serine protease inhibitors and migrating monocytes required for liver regeneration after 70% resection in mice.Frontiers in cell and developmental biology · 2023Article
- The gut microbiome contributes to splenomegaly and tissue inflammation in a murine model of primary biliary cholangitis.Annals of translational medicine · 2022Article
- Spleen: Reparative Regeneration and Influence on Liver.Life (Basel, Switzerland) · 2022Review
- Abnormalities of the composition of the gut microbiota and short-chain fatty acids in mice after splenectomy.Brain, behavior, & immunity - health · 2021Article
- Dynamic Alterations of the Gut Microbial Pyrimidine and Purine Metabolism in the Development of Liver Cirrhosis.Frontiers in molecular biosciences · 2021Article
- Geniposide Ameliorates Liver Fibrosis Through Reducing Oxidative Stress and Inflammatory Respose, Inhibiting Apoptosis and Modulating Overall Metabolism.Frontiers in pharmacology · 2021Article
- Microbiome and Metabolic Changes of Milk in Response to Dietary Supplementation With Bamboo Leaf Extract in Dairy Cows.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysbiosis of gut microbiota and metabolome is a frequently encountered condition in liver cirrhosis (LC) patients. The severity of liver dysfunction was found to be correlated with the degree of microbial dysbiosis. Several clinical studies have indicated liver function improvement after therapeutic splenectomy for LC-induced hypersplenism. We sought to determine whether such post-splenectomy outcome is pertinent to modulation of the abnormal gut microenvironment in LC patients. A cross-sectional study including 12 LC patients and 16 healthy volunteers was first conducted, then a before-after study in the cohort of patients was carried out before and 6 months after splenectomy. Fecal samples were collected in hospital. Temporal bacterial (
trial registrationChiCTR-OOB-15007409. Registered November 15, 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.