ReviewFrontiers in microbiology2018
Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.
Review in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Gut protozoa of wild rodents - a meta-analysis.Parasitology · 2024Pooled it
- Article
- Beyond Symbiosis: The Mind-Bending Role of Microbiomes in Host-Parasite Interactions.Molecular ecology · 2026Article
- Ectoparasitism and the gut microbiota: a cross-fostering experiment in a wild passerine.FEMS microbiology ecology · 2026Article
- Gut Integrity Biomarkers and Parasitic Infections in Indonesian Children: A Cross-Sectional Analysis.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- From parasite-induced immune activation to neuroinflammation and behavioral dysfunction: convergent mechanisms across protozoa and helminths: a review.Journal of neuroinflammation · 2026Review
- Systemic remodeling of the multi-organ virome following Echinococcus infection in mice.BMC microbiology · 2026Article
- Comparison of Gut Microbiota and Metabolic Characteristics Between Miechongshu-Treated and Untreated Yili Horses.Animals : an open access journal from MDPI · 2026Article
- The dual role of intestinal parasites in shaping human gut microbiota: distinguishing helminthic and protozoan dynamics.Gut pathogens · 2026Review
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Limited impact of schistosome infection on Biomphalaria glabrata snail microbiomes.Parasites & vectors · 2026Article
- Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns.NPJ biofilms and microbiomes · 2026Article
- Host traits and environmental factors shape infection heterogeneity in wild rat-protozoa networks.ISME communications · 2026Article
- Infection with gut parasites correlates with gut microbiome diversity across human populations in Africa.Gut microbes · 2025Article
- Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization.Nature communications · 2025Article
- Challenging the paradigm: the Asian fish tapeworm (Schyzocotyle acheilognathi, Yamaguti 1934) lacks an intrinsic symbiotic bacterial community.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Relationship of the Landscape Configuration with the Gut Parasites and Fungi Diversity in Farm Animals Associated with Conservation Areas in Colombia: Epidemiological Risk to Wildlife.Acta parasitologica · 2025Article
- Evolution and ecology of commensal gut protists: recent advances.Current opinion in genetics & development · 2025Review
- The ileal crypt ultrastructural changes accompanying cryptosporidiosis in type 1 diabetic mouse model versus dexamethasone-immunocompromised mouse model.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Insight into poultry coccidiosis: a dual focus on anticoccidial drugs and herbal plants for pharmacological and prevention strategies.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate gut teems with a large, diverse, and dynamic bacterial community that has pervasive effects on gut physiology, metabolism, and immunity. Under natural conditions, these microbes share their habitat with a similarly dynamic community of eukaryotes (helminths, protozoa, and fungi), many of which are well-known parasites. Both parasites and the prokaryotic microbiota can dramatically alter the physical and immune landscape of the gut, creating ample opportunities for them to interact. Such interactions may critically alter infection outcomes and affect overall host health and disease. For instance, parasite infection can change how a host interacts with its bacterial flora, either driving or protecting against dysbiosis and inflammatory disease. Conversely, the microbiota can alter a parasite's colonization success, replication, and virulence, shifting it along the parasitism-mutualism spectrum. The mechanisms and consequences of these interactions are just starting to be elucidated in an emergent transdisciplinary area at the boundary of microbiology and parasitology. However, heterogeneity in experimental designs, host and parasite species, and a largely phenomenological and taxonomic approach to synthesizing the literature have meant that common themes across studies remain elusive. Here, we use an ecological perspective to review the literature on interactions between the prokaryotic microbiota and eukaryotic parasites in the vertebrate gut. Using knowledge about parasite biology and ecology, we discuss mechanisms by which they may interact with gut microbes, the consequences of such interactions for host health, and how understanding parasite-microbiota interactions may lead to novel approaches in disease control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.