ArticleFrontiers in neurology2018
Aberrant Effective Connectivity of the Right Anterior Insula in Primary Insomnia.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review: auditory stimulation and sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Association of sleep symptom burden with default mode network homogeneity in first-episode drug-naïve adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Resting-State Functional Connectivity Alterations in Insomnia Disorder: A Systematic Review of Studies Published from 2020 to July 2025.Nature and science of sleep · 2026Review
- Article
- Factors Linking Interoception and Sleep Across the Adult Lifespan.Psychophysiology · 2025Article
- Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- Altered Insula Functional Connectivity Correlates to Cognitive Flexibility in Insomnia.Brain topography · 2025Article
- Stage-specific functional networks associated with cognitive impairment in Parkinson's disease: a pilot fNIRS study.Frontiers in aging neuroscience · 2025Article
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Homeostatic NREM sleep and salience network function in adult mice exposed to ethanol during development.Frontiers in neuroscience · 2023Article
- Review
- Abnormal functional connectivity of the salience network in insomnia.Brain imaging and behavior · 2022Article
- Hypogyrification in Generalized Anxiety Disorder and Associated with Insomnia Symptoms.Nature and science of sleep · 2022Article
- Brain Activity in Age-Related Macular Degeneration Patients From the Perspective of Regional Homogeneity: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Altered interhemispheric functional homotopy and connectivity in temporal lobe epilepsy based on fMRI and multivariate pattern analysis.Neuroradiology · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDaytime cognitive impairment is an essential symptom of primary insomnia (PI). However, the underlying neural substrate remains largely unknown. Many studies have shown that the right anterior insula (rAI) as a key node of salience network (SN) plays a critical role in switching between the executive control network (ECN) and the default mode network (DMN) for better performance of cognitively demanding tasks. Aberrant effective connectivity (directional functional connectivity) of rAI with ECN or DMN may be one reason for daytime cognitive impairment in PI patients. Up to now, no effective connectivity study has been conducted on patients with PI during resting state. Our aim is to investigate the effective connectivity between the rAI and the other voxels in the whole brain in PI. MATERIALS AND
methodsFifty drug-naive patients with PI and forty age- and sex-matched healthy controls were scanned using resting-state functional MRI. Seed-based Granger causality analysis was used to examine effective connectivity between the rAI, including ventral and dorsal part, and the whole brain. The effective connectivity was compared between the two groups and was correlated with clinical characteristics.
resultsCompared with controls, patients showed decreased effective connectivity from the rAI to the bilateral precuneus, the left postcentral gyrus (extending to bilateral precuneus) and the bilateral cerebellum posterior lobe, and decreased effective connectivity from the bilateral orbitofrontal cortex (OFC) to the rAI (single voxel
conclusionThe present study is the first to reveal aberrant effective connectivity between the SN hub (rAI) and the posterior DMN hub (precuneus) as well as decision-making region (OFC) and sensori-motor region in PI. These findings suggest an aberrant salience processing system of the rAI in PI patients.
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