Evidence map›Paper›PMID 29867712›Full record

ArticleFrontiers in neurology2018

High-Frequency Repetitive Magnetic Stimulation Enhances the Expression of Brain-Derived Neurotrophic Factor Through Activation of Ca

Ahreum Baek, Eun Jee Park, Soo Yeon Kim, Bae-Geun Nam, Ji Hyun Kim, Sang Woo Jun, Sung Hoon Kim, Sung-Rae Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  6. Tumor suppressive effect of low-frequency repetitive transcranial magnetic stimulation on glioblastoma progression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ahreum BaekDepartment of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Eun Jee ParkDepartment of Rehabilitation Medicine, The Graduate School Yonsei University Wonju College of Medicine, Wonju, South Korea.
Soo Yeon KimDepartment of Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Bae-Geun NamDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Ji Hyun KimDepartment of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Sang Woo JunDepartment of Biomedical Clinical Engineering, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Sung Hoon KimDepartment of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Sung-Rae ChoDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) can be used in various neurological disorders. However, neurobiological mechanism of rTMS is not well known. Therefore, in this study, we examined the global gene expression patterns depending on different frequencies of repetitive magnetic stimulation (rMS) in both undifferentiated and differentiated Neuro-2a cells to generate a comprehensive view of the biological mechanisms. The Neuro-2a cells were randomly divided into three groups-the sham (no active stimulation) group, the low-frequency (0.5 Hz stimulation) group, and high-frequency (10 Hz stimulation) group-and were stimulated 10 min for 3 days. The low- and high-frequency groups of rMS on Neuro-2a cells were characterized by transcriptome array. Differentially expressed genes were analyzed using the Database of Annotation Visualization and Integrated Discovery program, which yielded a Kyoto Encyclopedia of Genes and Genomes pathway. Amphetamine addiction pathway, circadian entrainment pathway, long-term potentiation (LTP) pathway, neurotrophin signaling pathway, prolactin signaling pathway, and cholinergic synapse pathway were significantly enriched in high-frequency group compared with low-frequency group. Among these pathways, LTP pathway is relevant to rMS, thus the genes that were involved in LTP pathway were validated by quantitative real-time polymerase chain reaction and western blotting. The expression of glutamate ionotropic receptor

Indexed as

brain-derived neurotrophic factorCa2+–calmodulin-dependent protein kinase II–cAMP-response element-binding protein pathwayhigh-frequencylow-frequencyNeuro-2a cellsrepetitive magnetic stimulation

Identifiers

PMID29867712
PMCPMC5949612
OpenAlexW2802002961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.