ArticleFrontiers in neurology2018
Association of Pre-Disease Body Mass Index With Multiple Sclerosis Prognosis.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Uncovering the Causal Link Between Obesity-Associated Genes and Multiple Sclerosis: A Systematic Literature Review.Brain and behavior · 2025Pooled it
- Pooled it
- Multiple sclerosis: molecular pathogenesis and therapeutic intervention.Signal transduction and targeted therapy · 2025Review
- Functional assessment of the dural lymphatic vessels using dynamic contrast MRI in multiple sclerosis.Brain and behavior · 2023Article
- An Ecological Analysis of Hospitalization Patterns for Diseases of the Nervous System in England and Wales over the Last 20 Years.Healthcare (Basel, Switzerland) · 2022Article
- Body mass index as a predictor of MS activity and progression among participants in BENEFIT.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case-control study.Neurosciences (Riyadh, Saudi Arabia) · 2022Article
- Temporal trends of incidence and prevalence of multiple sclerosis in Razavi Khorasan Province, Northeast Iran.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study.Neurology international · 2021Article
- Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study.Scientific reports · 2021Article
- Association of the global distribution of multiple sclerosis with ultraviolet radiation and air pollution: an ecological study based on GBD data.Environmental science and pollution research international · 2021Article
- Socioeconomic status and multiple sclerosis outcome.Nature reviews. Neurology · 2020Article
- High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system.Biochimica et biophysica acta. Molecular basis of disease · 2020Article
- Article
- The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients.Scientific reports · 2019Article
- Environmental and genetic risk factors for MS: an integrated review.Annals of clinical and translational neurology · 2019Review
- Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.EBioMedicine · 2019Article
- A Narrative Review Study on the Effects of Obesity and Bariatric Surgery on Multiple Sclerosis.Annals of Indian Academy of NeurologyArticle
- Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both high body mass index (BMI) and smoking tobacco are known risk factors for developing multiple sclerosis (MS). However, it is unclear whether BMI, like smoking, is a risk factor for the secondary progressive (SP) course. We, therefore, sought to determine if high/low BMI at age 20 is associated to risk of SP development, in the context of smoking status. Using data from MS patients with BMI and smoking information available, we examined relapsing onset patients with MS onset after 20 years of age. Cox regressions were conducted on smokers and non-smokers, with BMI as the main exposure. In total, 5,598 relapsing onset MS patients were included. The models demonstrated that BMI > 30 was associated to increased risk of SPMS in smokers (hazard ratio 1.50,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.