Evidence map›Paper›PMID 29867563›Full record

ArticleFrontiers in physiology2018

Investigating the Role of Interventricular Interdependence in Development of Right Heart Dysfunction During LVAD Support: A Patient-Specific Methods-Based Approach.

Kevin L Sack, Yaghoub Dabiri, Thomas Franz, Scott D Solomon, Daniel Burkhoff, Julius M Guccione

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Kevin L SackDivision of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Yaghoub DabiriDepartment of Surgery, University of California, San Francisco, San Francisco, CA, United States.
Thomas FranzDivision of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Scott D SolomonDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Daniel BurkhoffCardiovascular Research Foundation, New York, NY, United States.
Julius M GuccioneDepartment of Surgery, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USBrigham and Women's Hospital · USCardiovascular Research Foundation · USUniversity of Cape Town · ZA

Funding

Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS U01 HL119578
6 · The paper itself

Abstract

Predictive computation models offer the potential to uncover the mechanisms of treatments whose actions cannot be easily determined by experimental or imaging techniques. This is particularly relevant for investigating left ventricular mechanical assistance, a therapy for end-stage heart failure, which is increasingly used as more than just a bridge-to-transplant therapy. The high incidence of right ventricular failure following left ventricular assistance reflects an undesired consequence of treatment, which has been hypothesized to be related to the mechanical interdependence between the two ventricles. To investigate the implication of this interdependence specifically in the setting of left ventricular assistance device (LVAD) support, we introduce a patient-specific finite-element model of dilated chronic heart failure. The model geometry and material parameters were calibrated using patient-specific clinical data, producing a mechanical surrogate of the failing

Indexed as

finite element methodheart failuremechanical circulatory supportrealistic simulationright ventricleventricular assist deviceventricular function

Identifiers

PMID29867563
PMCPMC5962934
OpenAlexW2800144386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.