ArticleFrontiers in physiology2018
DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks.
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Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
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- Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease.Frontiers in molecular neuroscience · 2025Article
- Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers - Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer.Pharmacology & therapeutics · 2024Review
- Cigarette Smoke Modulates Inflammation and ImmunityAntioxidants & redox signaling · 2023Review
- Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.JCI insight · 2023Article
- Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.Frontiers in immunology · 2023Article
- 29 mJournal of immunology research · 2022Article
- Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation.Redox biology · 2021Article
- Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance.Journal of immunology research · 2021Article
- Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Frontiers in immunology · 2021Article
- Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.Frontiers in cardiovascular medicine · 2021Article
- Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.Frontiers in immunology · 2021Article
- ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes.Redox biology · 2020Review
- Potential Involvement of lncRNAs in the Modulation of the Transcriptome Response to Nodavirus Challenge in European Sea Bass (Biology · 2020Article
- Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells.International journal of molecular medicine · 2020Article
- Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept.Archives of biochemistry and biophysics · 2019Review
- Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions.Frontiers in oncology · 2019Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Huihong ZengDepartment of Histology and Embryology, Basic Medical School, Nanchang University, Nanchang, China.
Gayani K NanayakkaraCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ying ShaoCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Hangfei FuCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yu SunCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ramon CuetoCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
William Y YangCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Qian YangCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Haitao ShengCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Na WuCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Luqiao WangCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Wuping YangDepartment of Histology and Embryology, Basic Medical School, Nanchang University, Nanchang, China.
Hongping ChenDepartment of Histology and Embryology, Basic Medical School, Nanchang University, Nanchang, China.
Lijian ShaoJiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang, China.
Jianxin SunDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.
Xuebin QinDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Joon Y ParkCardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Konstantinos DrosatosCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Eric T ChoiCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Qingxian ZhuDepartment of Histology and Embryology, Basic Medical School, Nanchang University, Nanchang, China.
Hong WangCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaofeng YangCenter for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Temple University · USNanchang University · CNFirst Affiliated Hospital of Kunming Medical University · CNSheng Jing Hospital · CNThomas Jefferson University · USXijing Hospital · CN
Funding
CD40 monocyte in chronic kidney diseaseR01DK113775 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2017 to 2021
$3.3MHyperhomocysteinemia and HDL MetabolismR01HL117654 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2013 to 2017
$3.0MCaspase-1 activation mediates chronic kidney disease-accelerated atherosclerosisR01HL131460 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHOI, ERIC T., WANG, HONG · 2016 to 2019
$2.8MThe roles of miR-155 in regulating atherosclerosis and metabolically healthy obesityR01HL138749 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2017 to 2020
$2.6MNADHP Oxidase-mediated MC differentiation & Endothelial Dysfunction in HHcyR01HL110764 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2011 to 2015
$2.5MAtherogenic roles of complement systemR01HL130233 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI QIN, XUEBIN, WANG, HONG · 2016 to 2019
$2.5MIL-35 suppression of endothelial cell activation and atherosclerosisR01HL132399 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2017 to 2020
$2.3MFunctional implications of fluid shear stress-induced mitochondrial remodelingR01HL126952 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI PARK, JOON YOUNG · 2015 to 2019
$2.1MNHLBI NIH HHS R01 HL110764NHLBI NIH HHS R01 HL117654NHLBI NIH HHS R01 HL126952NHLBI NIH HHS R01 HL130233NHLBI NIH HHS R01 HL131460NHLBI NIH HHS R01 HL132399NHLBI NIH HHS R01 HL138749NIDDK NIH HHS R01 DK113775
Abstract
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair factors (DDRF) play a vital role in maintaining genomic integrity. However, how DDCFs and DDRFs are modulated under physiological and pathological conditions are not fully known. We took an experimental database analysis to determine the expression of 26 DNA DD
Indexed as
cancersdanger associated molecular patterns (DAMPs)DNA damage checkpoint and repair factorsgenomic instabilityinflammation
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