Evidence map›Paper›PMID 29867401›Full record

ArticleFrontiers in human neuroscience2018

Perinatal HIV Infection or Exposure Is Associated With Low

Frances C Robertson, Martha J Holmes, Mark F Cotton, Els Dobbels, Francesca Little, Barbara Laughton, André J W van der Kouwe, Ernesta M Meintjes

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  14. Frontiers in neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Frances C RobertsonMedical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Martha J HolmesMedical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Mark F CottonFamily Clinical Research Unit, Department of Paediatrics and Child Health, Tygerberg Children's Hospital and Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Els DobbelsFamily Clinical Research Unit, Department of Paediatrics and Child Health, Tygerberg Children's Hospital and Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Francesca LittleDepartment of Statistical Sciences, Faculty of Sciences, University of Cape Town, Cape Town, South Africa.
Barbara LaughtonFamily Clinical Research Unit, Department of Paediatrics and Child Health, Tygerberg Children's Hospital and Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
André J W van der KouweA. A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States.
Ernesta M MeintjesMedical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAStellenbosch University · ZAMassachusetts General Hospital · USTygerberg Children’s Hospital · ZA

Funding

Longitudinal, multimodal analysis of HIV and ART effects on brain metabolism, structure and connectivity in young childrenR21MH108346 · NIMH · UNIVERSITY OF CAPE TOWN · PI BISWAL, BHARAT BHUSAN, MEINTJES, ERNESTA MARIA · 2015 to 2016
$298k
NIMH NIH HHS R21 MH108346
6 · The paper itself

Abstract

Abnormalities of the basal ganglia are frequently seen in HIV-infected (HIV+) children despite antiretroviral treatment (ART) initiation during childhood. Assessment of metabolites associated with neuronal integrity or with glial proliferation can present a sensitive description of metabolic events underlying basal ganglia structural changes. We used magnetic resonance spectroscopy to examine differences in creatine, choline,

Indexed as

basal gangliaearly ART initiationglutamateHIVHIV exposuremagnetic resonance spectroscopyNAA

Identifiers

PMID29867401
PMCPMC5949349
OpenAlexW2801970632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.