ArticleFrontiers in behavioral neuroscience2018
Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Social isolation, rather than kinship, influences association behavior in toad tadpoles (Bufo formosus).Animal cognition · 2026Article
- Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.Brain, behavior, & immunity - health · 2026Article
- Activation of a locus coeruleus to ventral tegmental area noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in TH-ires-Cre mice.Neuropharmacology · 2026Article
- Behavioral impact of adolescent social isolation stress: A multidimensional assessment in male NMRI mice.Learning & behavior · 2026Article
- The relationship between social isolation, depressive symptoms and cognitive function in older adults: a longitudinal mediation study in China.Social psychiatry and psychiatric epidemiology · 2025Article
- Golgi-Cox Staining Protocol for Medium Spiny Neurons in the Striatum of Neonatal and Early Postnatal Mouse Brain Using Cryosections.International journal of molecular sciences · 2025Article
- Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation.Nature communications · 2025Article
- Brain State-Dependent Neocortico-Hippocampal Network Dynamics Are Modulated by Postnatal Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies.Biological psychiatry · 2024Review
- Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction.Psychiatry research · 2024Article
- Recovery from social isolation requires dopamine in males, but not the autism-related geneRoyal Society open science · 2024Article
- Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex.Cells · 2024Article
- Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation.Scientific reports · 2024Article
- Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats.Neurobiology of stress · 2024Article
- Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse.Frontiers in neuroanatomy · 2024Review
- The therapeutic potential of traditional Chinese medicine in depression: focused on the modulation of neuroplasticity.Frontiers in pharmacology · 2024Review
- Social isolation leads to mild social recognition impairment and losses in brain cellularity.Brain structure & function · 2023Article
- SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain.Neuroscience · 2023Article
- Individualized Housing Modifies the Immune-Endocrine System in CD1 Adult Male Mice.Animals : an open access journal from MDPI · 2023Article
- Comparison of the effect of postweaning social isolation, enriched environment, and exercise training on learning and memory functions in rats.Turkish journal of medical sciences · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice socially isolated during adolescence exhibit behaviors of anxiety, depression and impaired social interaction. Although these behaviors are well documented, very little is known about the associated neurobiological changes that accompany these behaviors. It has been hypothesized that social isolation during adolescence alters the development of the prefrontal cortex, based on similar behavioral abnormalities observed in isolated mice and those with disruption of this structure. To establish relationships between behavior and underlying neurobiological changes in the prefrontal cortex, Thy-1-GFP mice were isolated from weaning until adulthood and compared to group-housed littermates regarding behavior, electrophysiological activity and dendritic morphology. Results indicate an immaturity of dendritic spines in single housed animals, with dendritic spines appearing smaller and thinner. Single housed mice additionally show impaired plasticity through measures of long-term potentiation. Together these findings suggest an altered development and impairment of the prefrontal cortex of these animals underlying their behavioral characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.