Evidence map›Paper›PMID 29867381›Full record

ArticleFrontiers in systems neuroscience2018

Scaling of Optogenetically Evoked Signaling in a Higher-Order Corticocortical Pathway in the Anesthetized Mouse.

Xiaojian Li, Naoki Yamawaki, John M Barrett, Konrad P Körding, Gordon M G Shepherd

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in systems neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Dysregulation of the Basal Ganglia Indirect Pathway in Early SymptomaticThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  4. Incerto-thalamic modulation of fear via GABA and dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  5. Review
  6. Review
  7. Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xiaojian LiDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Naoki YamawakiDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
John M BarrettDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Konrad P KördingDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Gordon M G ShepherdDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

Funding

Synaptic Circuit Organization of Motor CortexR01NS061963 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHEPHERD, GORDON M · 2008 to 2022
$5.4M
Microconnectomics of neocortex: a multiscale computer modelU01EB017695 · NIBIB · SUNY DOWNSTATE MEDICAL CENTER · PI LYTTON, WILLIAM W · 2014 to 2017
$2.3M
Synaptic circuit organization of motor cortexR37NS061963 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gordon M Shepherd · 2024 to 2026
$1.6M
NIBIB NIH HHS U01 EB017695NINDS NIH HHS R01 NS061963NINDS NIH HHS R37 NS061963
6 · The paper itself

Abstract

Quantitative analysis of corticocortical signaling is needed to understand and model information processing in cerebral networks. However, higher-order pathways, hodologically remote from sensory input, are not amenable to spatiotemporally precise activation by sensory stimuli. Here, we combined parametric channelrhodopsin-2 (ChR2) photostimulation with multi-unit electrophysiology to study corticocortical driving in a parietofrontal pathway from retrosplenial cortex (RSC) to posterior secondary motor cortex (M2) in mice

Indexed as

channelrhodopsincorticocorticalelectrophysiologymodelingoptogeneticssilicon probe

Identifiers

PMID29867381
PMCPMC5962832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.