ArticleFrontiers in cellular neuroscience2018
Cell Mechanotransduction With Piconewton Forces Applied by Optical Tweezers.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Noninvasive biophysical modulations of Piezo ion channels.Microsystems & nanoengineering · 2026Review
- Robust quantification of cellular mechanics using optical tweezers.Biophysical reports · 2025Article
- Multimodal Characterization of Cortical Neuron Response to Permanent Magnetic Field Induced Nanomagnetic Force Maps.ACS nano · 2024Article
- Force versus Response: Methods for Activating and Characterizing Mechanosensitive Ion Channels and GPCRs.Advanced healthcare materials · 2024Review
- Optical tweezers in biomedical research - progress and techniques.Journal of medicine and life · 2024Review
- An optical system for cellular mechanostimulation in 3D hydrogels.Acta biomaterialia · 2024Article
- Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm.Frontiers in oncology · 2024Article
- Single-neuron mechanical perturbation evokes calcium plateaus that excite and modulate the network.Scientific reports · 2023Article
- Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development.Nature communications · 2023Article
- The energetics of rapid cellular mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Experimental characterization, modelling and compensation of temperature effects in optotunable lenses.Scientific reports · 2023Article
- The effects of mechanical force on fibroblast behavior in cutaneous injury.Frontiers in surgery · 2023Review
- Optical tweezers across scales in cell biology.Trends in cell biology · 2022Review
- Mechanotransduction in hippocampal neurons operates under localized low picoNewton forces.iScience · 2022Article
- Biophysical Approaches for Applying and Measuring Biological Forces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Nano-Precision Tweezers for Mechanosensitive Proteins and Beyond.Molecules and cells · 2022Review
- Biomechanical properties of native and cultured red blood cells-Interplay of shape, structure and biomechanics.Frontiers in physiology · 2022Article
- Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.International journal of molecular sciences · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical stresses are always present in the cellular environment and mechanotransduction occurs in all cells. Although many experimental approaches have been developed to investigate mechanotransduction, the physical properties of the mechanical stimulus have yet to be accurately characterized. Here, we propose a mechanical stimulation method employing an oscillatory optical trap to apply piconewton forces perpendicularly to the cell membrane, for short instants. We show that this stimulation produces membrane indentation and induces cellular calcium transients in mouse neuroblastoma NG108-15 cells dependent of the stimulus strength and the number of force pulses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.