ArticleNature genetics2018
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer.
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The trial behind it
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Who cites it
45 citing papers in PubMed.
- Comparative Functional Effects of Abemaciclib and Arcyriaflavin A inInternational journal of molecular sciences · 2026Article
- Article
- Fractal Dimension of High-Risk Neuroblastoma Vascularity in MRI Is Associated with Chemotherapy Response and Event-Free Survival.Radiology. Imaging cancer · 2026Article
- Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing.The Journal of pathology · 2025Article
- Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions.The Journal of pathology · 2025Article
- Evolutionary unpredictability in cancer model systems.Scientific reports · 2025Article
- High resolution clonal architecture of hypomutated Wilms tumours.Nature communications · 2025Article
- Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity.Cell & bioscience · 2025Article
- Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma.Nature communications · 2024Article
- Review
- Hallmark discoveries in the biology of Wilms tumour.Nature reviews. Urology · 2024Review
- Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Clonal evolution during metastatic spread in high-risk neuroblastoma.Nature genetics · 2023Article
- Spatial biology of cancer evolution.Nature reviews. Genetics · 2023Review
- Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.Nature genetics · 2023Article
- Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy.Oncoimmunology · 2023Article
- Targeted Epigenetic Interventions in Cancer with an Emphasis on Pediatric Malignancies.Biomolecules · 2022Review
- Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors.Scientific reports · 2022Article
- Clonal diversification and histogenesis of malignant germ cell tumours.Nature communications · 2022Article
- Spatial structure governs the mode of tumour evolution.Nature ecology & evolution · 2022Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.