Evidence map›Paper›PMID 29867215›Full record

ArticleNature structural & molecular biology2018

Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM.

Felipe Merino, Sabrina Pospich, Johanna Funk, Thorsten Wagner, Florian Küllmer, Hans-Dieter Arndt, Peter Bieling, Stefan Raunser

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 213 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. ADPact: A versatile sensor for ADP-F-actin.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Mapping the interaction surface between CaNature communications · 2025
    Article
  16. Article
  17. Structure of the F-tractin-F-actin complex.The Journal of cell biology · 2025
    Article
  18. Article
  19. Review
  20. Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Felipe MerinoDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0003-4166-8747
Sabrina PospichDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0002-5119-3039
Johanna FunkDepartment of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Thorsten WagnerDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0002-1550-8275
Florian KüllmerInstitute of Organic and Macromolecular Chemistry, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-0671-1546
Hans-Dieter ArndtInstitute of Organic and Macromolecular Chemistry, Friedrich-Schiller-Universität Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-0792-1422
Peter BielingDepartment of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Stefan RaunserDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany. stefan.raunser@mpi-dortmund.mpg.de.ORCID http://orcid.org/0000-0001-9373-3016
Max Planck Institute of Molecular Physiology · DEFriedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of actin is coupled to the nucleotide bound to its active site. ATP hydrolysis is activated during polymerization; a delay between hydrolysis and inorganic phosphate (P

Indexed as

4-ButyrolactoneAcetogeninsActinsAdenosine DiphosphateAdenosine TriphosphateAnimalsCryoelectron MicroscopyDepsipeptidesHydrolysisMicrofilament ProteinsMuscle, SkeletalPhosphatesProtein BindingProtein ConformationRabbits4-ButyrolactoneAcetogeninsActinsAdenosine DiphosphateAdenosine Triphosphatecoronin acetogeninDepsipeptidesjasplakinolideMicrofilament ProteinsPhosphates

Identifiers

PMID29867215
OpenAlexW2805664184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.