ArticleScientific reports2018
Quantitative analysis of DNA with single-molecule sequencing.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Chiral discrimination of amino acids in meteorite and desert soil extracts via single-molecule nanogap conductance.Nature communications · 2026Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Direct observation of DNA alterations induced by a DNA disruptor.Scientific reports · 2022Article
- Single-molecule junction spontaneously restored by DNA zipper.Nature communications · 2021Article
- Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC.Scientific reports · 2021Article
- Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway.Nanomaterials (Basel, Switzerland) · 2021Article
- Single-Molecule Counting of Nucleotide by Electrophoresis with Nanochannel-Integrated Nano-Gap Devices.Micromachines · 2020Article
- Advances in Label-Free Detections for Nanofluidic Analytical Devices.Micromachines · 2020Review
- Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.Scientific reports · 2020Article
- Solid-state nanopores towards single-molecule DNA sequencing.Journal of human genetics · 2020Review
- Significant epitranscriptomes in heterogeneous cancer.Cancer science · 2019Review
- Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer can be diagnosed by identifying DNA and microRNA base sequences that have the same base length yet differ in a few base sequences, if the abundance ratios of these slightly deviant base sequences can be determined. However, such quantitative analyses cannot be performed using the current DNA sequencers. Here we determine entire base sequences of four types of DNA corresponding to the let-7 microRNA, which is a 22-base cancer marker. We record the single-molecule conductances of the base molecules using current-tunneling measurements. In addition, we count the numbers of molecules in a solution to determine the abundance ratios of two DNA strands that differ by a single base sequence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.